Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Biological ActivityPotent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.
Guo et al.
EMBO Mol.Med., 2010;2:504
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for MSC 2032964A
There are currently no reviews for this product. Be the first to review MSC 2032964A and earn rewards!
Have you used MSC 2032964A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image