MSC 2032964A

Catalog # Availability Size / Price Qty
5641/50
5641/10
Cat.No. 5641 - MSC 2032964A | C16H13F3N6O | CAS No. 1124381-43-6
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Description: Potent and selective ASK1 inhibitor; orally bioavailable

Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
362.31
Formula:
C16H13F3N6O
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1124381-43-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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