Potent and selective ASK1 inhibitor (IC50
= 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.
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All Tocris products are intended for laboratory research use only.
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.
Guo et al.
EMBO Mol.Med., 2010;2:504