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MSC 2032964A

Catalog #: 5641 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5641/50
5641/10
MSC 2032964A | CAS No. 1124381-43-6 | ASK1 Inhibitors
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Description: Potent and selective ASK1 inhibitor; orally bioavailable

Chemical Name: N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide

Purity: ≥98%

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Biological Activity

MSC 2032964A is a potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant.

Technical Data

M.Wt:
362.31
Formula:
C16H13F3N6O
Solubility:
Soluble to 20 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1124381-43-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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