mobilizing agent. Initiates Ca2+
release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+
release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+
from acidic organelles.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft et al.
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
Dammerman et al.
The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:
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