NAADP tetrasodium salt
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Biological ActivityNAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft PJ, Ruas M, Pan Z et al.
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
Dammerman et al.
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
Citations for NAADP tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:
3 Citations: Showing 1 - 3
Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.
Authors: Hadi Et al.
Nat Commun 2018;9:5022
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
Authors: Ruas Et al.
Am J Physiol Gastrointest Liver Physiol 2015;NULL
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Authors: Wang Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for NAADP tetrasodium salt
There are currently no reviews for this product. Be the first to review NAADP tetrasodium salt and earn rewards!
Have you used NAADP tetrasodium salt?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image