NAADP tetrasodium salt

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NAADP tetrasodium salt | Ryanodine Receptor Modulators
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Description: Ca2+ mobilizing agent
Alternative Names: NAADP

Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt

Purity: ≥98%

Product Details
Citations (3)

Biological Activity

NAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.

Technical Data

Soluble to 50 mM in water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. NAADP mobilizes calcium from acidic organelles through two-pore channels.
    Calcraft PJ, Ruas M, Pan Z et al.
  2. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
    Dammerman et al.
    Proc.Natl.Acad.Sci., 2009;106:10678
  3. NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
    Biochem.Soc.Transactions, 2006;34:922

Product Datasheets

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Citations for NAADP tetrasodium salt

The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

3 Citations: Showing 1 - 3


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