Catalog Number: 3905
Alternate Names: NAADP
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Biological Activity
Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.
Technical Data
  • M.Wt:
    832.32
  • Formula:
    C21H23N6Na4O18P3
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    5502-96-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NAADP mobilizes calcium from acidic organelles through two-pore channels.
    Calcraft et al.
    Nature, 2009;459:596
  2. NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
    Dammerman et al.
    Proc.Natl.Acad.Sci., 2009;106:10678
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:

2 Citations: Showing 1 - 2
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  1. Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
    Authors: Ruas Et al.
    Am J Physiol Gastrointest Liver Physiol 2015;NULL
  2. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
    Authors: Wang Et al.
    Cell 2012;151:372

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