NAADP tetrasodium salt
Chemical Name: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Biological ActivityNAADP tetrasodium salt is a Ca2+ mobilizing agent. Initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca2+ from acidic organelles.
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NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft PJ, Ruas M, Pan Z et al.
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist.
Dammerman et al.
NAADP, a new intracellular messenger that mobilizes Ca2+ from acidic stores.
Citations for NAADP tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for NAADP tetrasodium salt include:
3 Citations: Showing 1 - 3
Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells.
Authors: Hadi Et al.
Nat Commun 2018;9:5022
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
Authors: Ruas Et al.
Am J Physiol Gastrointest Liver Physiol 2015;NULL
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Authors: Wang Et al.
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