Catalog Number: 1568
Alternate Names: N-Arachidonyldopamine, AA-DA
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity
Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1 over CB2 receptors (Ki values are 0.25 and 12 μM respectively), and potent agonist at TRPV1 (VR1) receptors (EC50 ~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.
    Bisogno et al.
    Biochem.J., 2000;351:817
  2. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.
    De Petrocellis et al.
    FEBS Lett., 2000;483:52
  3. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
    Huang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2002;99:8400

The citations listed below are publications that use Tocris products. Selected citations for NADA include:

Showing Results 1 - 2 of 2

  1. Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH.
    Authors: Kaszás Et al.
    PLoS One
  2. Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia.
    Authors: Pitcher Et al.
    J Pharmacol Exp Ther
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