Potent endogenous cannabinoid and vanilloid receptor agonist, with no action at dopamine receptors. Selective for CB1
values are 0.25 and 12 μ
M respectively), and potent agonist at TRPV1 (VR1) receptors (EC50
~ 50 nM). Metabolically stable and competitively inhibits FAAH and anandamide transport. Has cannabinoid and vanilloid actions in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
N-acyl-dopamines: novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo.
Bisogno et al.
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.
De Petrocellis et al.
FEBS Lett., 2000;483:52
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
Huang et al.
The citations listed below are publications that use Tocris products. Selected citations for NADA include:
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