Catalog Number: 1347
Chemical Name: N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide
Biological Activity
Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration.
Technical Data
  • M.Wt:
    365.47
  • Formula:
    C22H27N3O2
  • Solubility:
    Soluble to 100 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    149649-22-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of INSERM and BIOPROJET
Background References
  1. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.
    Audinot et al.
    J.Pharmacol.Exp.Ther., 1998;287:187
  2. Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.
    Sautel et al.
    J.Pharmacol.Exp.Ther., 1995;275:1239
  3. The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine.
    Richtand et al.
    Brain Res., 2000;867:239
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nafadotride include:

2 Citations: Showing 1 - 2
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  1. Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord.
    Authors: Brewer Et al.
    Front Neural Circuits 2014;8:62
  2. Conversion of the modulatory actions of dopamine on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.
    Authors: Clemens and Hochman
    J Neurosci 2004;24:11337

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