Nafadotride
Discontinued Product
Chemical Name: N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide
Purity: ≥98%
Biological Activity
Highly potent, competitive, preferential dopamine D3 receptor antagonist. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Centrally active upon systemic administration.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
A comparative in vitro and in vivo pharmacological characterization of the novel DA D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194.
Audinot et al.
J.Pharmacol.Exp.Ther., 1998;287:187 -
The DA D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine.
Richtand et al.
Brain Res., 2000;867:239 -
Nafadotride, a potent preferential DA D3 receptor antagonist, activates locomotion in rodents.
Sautel et al.
J.Pharmacol.Exp.Ther., 1995;275:1239
Product Datasheets
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Citations for Nafadotride
The citations listed below are publications that use Tocris products. Selected citations for Nafadotride include:
2 Citations: Showing 1 - 2
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DA D3 receptor dysfunction prevents anti-nociceptive effects of mor. in the spinal cord.
Authors: Brewer Et al.
Front Neural Circuits 2014;8:62
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Conversion of the modulatory actions of DA on spinal reflexes from depression to facilitation in D3 receptor knock-out mice.
Authors: Clemens and Hochman
J Neurosci 2004;24:11337
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