Nafarelin

Name: Nafarelin
Brand: Tocris Bioscience
SKU: 2544

Catalog #: 2544 Datasheet / COA / SDS

Discontinued Product

2544 has been discontinued.

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Description: GnRH receptor agonist

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Nafarelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Repeated administration causes desensitization of pituitary GnRH receptors resulting in inhibition of gonadotropin release and decreased steroid hormone synthesis. Induces atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia.

Technical Data

M.Wt:

1322

Formula:

C₆₆H₈₃N₁₇O₁₃

Sequence:

XEHWSYXLRPG

(Modifications: X-1 = Glp, X-2 = 2-Nal, Gly-10 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

76932-56-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions.
Chrisp and Goa
Drugs, 1990;39:523
Nafarelin acetate: a gonadotrophin-releasing hormone agonist for the treatment of endometriosis.
Letassy et al.
DICP, 1990;24:1204
Effect of gonadotrophin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat.
Mizutani et al.
Int.J.Fertil.Menopausal Stud., 1995;40:106

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

⚠ WARNING: This product can expose you to chemicals including Nafarelin acetate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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