Catalog Number: 0740
Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride
Biological Activity
Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ� and κ opioid receptors.
Technical Data
  • M.Wt:
    450.96
  • Formula:
    C26H26N2O3.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    111469-81-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota.
Background References
  1. The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.
    Shippenberg and Heidbreder
    Eur.J.Pharmacol., 1995;280:55
  2. Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
    Ossipov et al.
    Neurosci. Lett., 1994;181:9
  3. Design of peptidomimetic δ opioid receptor antagonists using the message-address concept.
    Portoghese et al.
    J.Med.Chem., 1990;33:1714
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Naltrindole hydrochloride include:

12 Citations: Showing 1 - 10
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  1. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Diabetes 2015;22:49
  2. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    J Biomed Sci 2015;172:642
  3. Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration.
    Authors: Bigliardi Et al.
    PLoS One 2015;172:501
  4. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    J Neurosci 2015;10:e0145556
  5. Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
    Authors: van Cleef Et al.
    Antiviral Res. 2013;99:165
  6. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Am J Physiol Heart Circ Physiol 2013;38:1296
  7. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    Br J Pharmacol 2013;305:H1246
  8. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neuropsychopharmacology 2011;31:13068
  9. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.
    Authors: Sánchez-Blázquez Et al.
    PLoS One 2010;5:e11278
  10. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci 2010;32:1278
  11. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Neuropsychopharmacology 2009;2011:159209
  12. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Br J Pharmacol 2007;32:399
Expand to show all 12 Citations

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