Naltrindole hydrochloride

  ( 18 citations )    
Product Datasheet
Catalog Number:0740
Chemical Name:17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride
Product Details
Citations (18)
Supplemental Products
Reviews
Biological Activity
Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.
Technical Data
  • M.Wt:
    450.96
  • Formula:
    C26H26N2O3.HCl
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    111469-81-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Naltrindole hydrochloride include:

18 Citations: Showing 1 - 10
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  1. Cytoprotection against Hypoxic and/or MPP? Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
    Authors: Xu Et al.
    Int J Mol Sci  2016;17
  2. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Diabetes  2015;22:49
  3. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    J Biomed Sci  2015;172:642
  4. Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration.
    Authors: Bigliardi Et al.
    PLoS One  2015;172:501
  5. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.
    Authors: Neumann Et al.
    J Invest Dermatol  2015;135:471
  6. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    J Neurosci  2015;10:e0145556
  7. δ-opioid and dopaminergic processes in accumbens shell modulate the cholinergic control of predictive learning and choice.
    Authors: Laurent Et al.
    J Neurosci  2014;34:1358
  8. Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
    Authors: van Cleef Et al.
    Antiviral Res.  2013;99:165
  9. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Am J Physiol Heart Circ Physiol  2013;38:1296
  10. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    Br J Pharmacol  2013;305:H1246
  11. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  12. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neuropsychopharmacology  2011;31:13068
  13. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.
    Authors: Sánchez-Blázquez Et al.
    PLoS One  2010;5:e11278
  14. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci  2010;32:1278
  15. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  16. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.
    Authors: Choi Et al.
    Korean J Pain  2010;23:236
  17. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Neuropsychopharmacology  2009;2011:159209
  18. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Br J Pharmacol  2007;32:399
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