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Naltrindole hydrochloride

Catalog #: 0740
24 Citations Datasheet / COA / SDS

Discontinued Product

0740 has been discontinued.
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Naltrindole hydrochloride | CAS No. 111469-81-9 | delta Opioid Receptor Antagonists
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Description: Selective non-peptide δ antagonist

Chemical Name: 17-(Cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride

Purity: ≥99%

Product Details
Citations (24)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors.

Technical Data

M.Wt:
450.96
Formula:
C26H26N2O3.HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
111469-81-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the University of Minnesota.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat.
    Harte-Hargrove L, Varga-Wesson A, Duffy A, Milner T, Scharfman H
    J Neurosci, 2015;35(4):1723-38.
  3. Development of functionally selective, small molecule agonists at kappa opioid receptors.
    Zhou L, Lovell K, Frankowski K, Slauson S, Phillips A, Streicher J, Stahl E, Schmid C, Hodder P, Madoux F, Cameron M, Prisinzano T, Aube J, Bohn L
    J Biol Chem, 2013;288(51):36703-16.
  4. Naltrindole, an opioid δ antagonist, blocks the enhancement of morphine-antinociception induced by a CCKB antagonist in the rat.
    Ossipov et al.
    Neurosci. Lett., 1994;181:9
  5. The δ-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine.
    Shippenberg and Heidbreder
    Eur.J.Pharmacol., 1995;280:55
  6. Design of peptidomimetic δ opioid receptor antagonists using the message-address concept.
    Portoghese et al.
    J.Med.Chem., 1990;33:1714

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Citations for Naltrindole hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Naltrindole hydrochloride include:

24 Citations: Showing 1 - 10

  1. Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
    Authors: Nasrallah Et al.
    Cell Rep  2019;27:86
  2. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  3. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.
    Authors: Schmid Et al.
    Cell  2017;171:1165
  4. Cytoprotection against Hypoxic and/or MPP? Injury: Effect of δ-Opioid Receptor Activation on Caspase 3.
    Authors: Xu Et al.
    Int J Mol Sci  2016;17
  5. Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice.
    Authors: Smith Et al.
    Proc Natl Acad Sci U S A  2016;113:13893
  6. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Diabetes  2015;22:49
  7. Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors.
    Authors: Schuster Et al.
    J Biomed Sci  2015;172:642
  8. Activation of the δ-opioid receptor promotes cutaneous wound healing by affecting keratinocyte intercellular adhesion and migration.
    Authors: Bigliardi Et al.
    PLoS One  2015;172:501
  9. The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.
    Authors: Neumann Et al.
    J Invest Dermatol  2015;135:471
  10. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    J Neurosci  2015;10:e0145556
  11. δ-opioid and DArgic processes in accumbens shell modulate the cholinergic control of predictive learning and choice.
    Authors: Laurent Et al.
    J Neurosci  2014;34:1358
  12. Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.
    Authors: van Cleef Et al.
    Antiviral Res.  2013;99:165
  13. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Am J Physiol Heart Circ Physiol  2013;38:1296
  14. Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
    Authors: Leal Et al.
    Br J Pharmacol  2013;305:H1246
  15. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  16. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  17. Activation of spinal mu- and δ-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
    Authors: Beaudry Et al.
    Neuropsychopharmacology  2011;31:13068
  18. Mu-opioid receptors transiently activate the Akt-nNOS pathway to produce sustained potentiation of PKC-mediated NMDAR-CaMKII signaling.
    Authors: Sánchez-Blázquez Et al.
    PLoS One  2010;5:e11278
  19. Alterations of CXCR4 function in μ-opioid receptor-deficient glia.
    Authors: Burbassi Et al.
    Eur J Neurosci  2010;32:1278
  20. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  21. Roles of opioid receptor subtype in the spinal antinociception of selective cyclooxygenase 2 inhibitor.
    Authors: Choi Et al.
    Korean J Pain  2010;23:236
  22. Coexpression of delta- and mu-opioid receptors in nociceptive sensory neurons.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2010;107:13117
  23. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    Neuropsychopharmacology  2009;2011:159209
  24. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Br J Pharmacol  2007;32:399

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