NCOR2 Antibody (1542)

Name: NCOR2 Antibody (1542)
Brand: Novus Biologicals
SKU: NB120-2781
Price: 399 USD
Availability: InStock

Novus Biologicals | Catalog # NB120-2781

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Product Documents

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot, Chromatin Immunoprecipitation (ChIP)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG₁ Clone # 1542

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Product Specifications

Immunogen

Synthetic peptide corresponding to residues C G G A(2016) S A S D P H R E K T Q(2027) of human NCOR2.

Specificity

NCoR2 - CHIP Grade (1542)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Scientific Data Images for NCOR2 Antibody (1542)

Western Blot: NCOR2 Antibody (1542) [NB120-2781]

Western Blot: NCOR2 Antibody (1542) [NB120-2781] - Analysis of 25 ug of Hela (lane 1) and Neuro-2a (lane 2) cell lysates.

Applications for NCOR2 Antibody (1542)

Application

Recommended Usage

Chromatin Immunoprecipitation (ChIP)

1:10-1:500

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Western Blot

4 ug/ml

Application Notes

ChIP: Use 3ul for 10^6 cells. WB: Detects a band of approx. 220 and 250 kDa (predicted molecular weight: 274 kDa). May be useful in IHC-Fr and ICC/IF. May be block with Retinoic Acid Receptor alpha peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: NCOR2

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing Mediator of Retinoic acid & Thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.

Long Name

Nuclear Receptor Co-repressor 2

Alternate Names

CTG26, SMRT, SMRTE, TNRC14, TRAC-1

Entrez Gene IDs

9612 (Human)

Gene Symbol

NCOR2

Additional NCOR2 Products

Product Documents for NCOR2 Antibody (1542)

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Certificate of Analysis

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Product Specific Notices for NCOR2 Antibody (1542)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Notch Pathway

Nuclear Hormone Receptors and Regulators

Stem Cell Transcription Factors and Regulators

Citations for NCOR2 Antibody (1542)

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