Mammalian bombesin-like peptide and endogenous ligand for the neuromedin B receptor (IC50
= 2 nM); first isolated from pig spinal cord. Regulates endocrine and exocrine secretion, smooth muscle contraction, blood pressure, feeding and cell growth.
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Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord.
Minamino et al.
Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.
Sainz et al.
Ohki-Hamazaki et al.