Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50
= 16.7 nM for inhibition of [Trp11
]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo
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Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases.
Checler et al.
Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors.
Dubuc et al.
Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.
Minamino et al.