Catalog Number: 1907
Biological Activity
Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo.
Technical Data
  • M.Wt:
    745.96
  • Formula:
    C38H63N7O8
  • Sequence:
    KIPYIL
  • Solubility:
    Soluble to 0.50 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    92169-45-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuromedin N: high affinity interaction with neurotensin receptors and rapid inactivation by brain synaptic peptidases.
    Checler et al.
    Eur.J.Pharmacol., 1986;126:239
  2. Hypothermic effect of neuromedin N in mice and its potentiation by peptidase inhibitors.
    Dubuc et al.
    Eur.J.Pharmacol., 1988;151:117
  3. Neuromedin N: a novel neurotensin-like peptide identified in porcine spinal cord.
    Minamino et al.
    Biochem.Biophys.Res.Commun., 1984;122:542

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