Catalog Number: 1917
Biological Activity
Endogenous peptide regulating blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Also decreases food intake and body weight, increases body temperature and heat production, and inhibits gastric acid secretion via the CRH system following central administration in vivo.
Technical Data
  • M.Wt:
    2643
  • Formula:
    C124H180N34O31
  • Sequence:
    YKVNEYQGPVAPSGGFFLFRPRN

    (Modifications: Asn-23 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    117505-80-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuromedin U acts in the cental nervous system to inhibit gastric acid secretion via CRH system.
    Mondal et al.
    Am.J.Physiol.Gastrointest.Liver Physiol., 2003;284:G963
  2. Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord.
    Minamino et al.
    Biochem.Biophys.Res.Commun., 1985;130:1078
  3. Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.
    Szekeres et al.
    J.Biol.Chem., 2000;275:20247

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