Endogenous peptide regulating blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function. Also decreases food intake and body weight, increases body temperature and heat production, and inhibits gastric acid secretion via the CRH system following central administration in vivo
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Neuromedin U acts in the cental nervous system to inhibit gastric acid secretion via CRH system.
Mondal et al.
Am.J.Physiol.Gastrointest.Liver Physiol., 2003;284:G963
Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord.
Minamino et al.
Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3.
Szekeres et al.