Catalog Number: 3009
Alternate Names: NPW-23
Biological Activity
Endogenous peptide agonist of Neuropeptide B/Neuropeptide W receptors NPBW1 and NPBW2 (previously known as GPR7 and GPR8 respectively). Increases food intake following injection into the paraventricular nucleus.
Technical Data
  • M.Wt:
    2584.03
  • Formula:
    C119H183N35O28S
  • Sequence:
    WYKHVASPRYHTVGRAAGLLMGL
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    383415-79-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.
    Shimomura et al.
    J.Biol.Chem., 2002;277:35826
  2. Identification of natural ligands for the orphan G prortein-coupled receptors GPR7 and GPR8.
    Brezillon et al.
    J.Biol.Chem., 2003;278:776
  3. Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake.
    Levine et al.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2005;288:R1727
  4. The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion.
    Hondo et al.
    Results Probl.Cell Differ., 2008;46:239

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