NF 340

Name: NF 340
Brand: Tocris Bioscience
SKU: 3830

Catalog #: 3830
7 Citations Datasheet / COA / SDS

Discontinued Product

3830 has been discontinued.

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NF 340 | CAS No. 202982-98-7 | P2Y Receptor Antagonists

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Description: Selective P2Y11 antagonist

Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt

Purity: ≥95%

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Product Details

Citations (7)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

P2Y₁₁ antagonist; exhibits 520-fold selectivity for P2Y₁₁ over P2Y₁, P2Y₂, P2Y₄, P2Y₆ and P2Y₁₂ receptors. Displays competitive antagonism against ATPγS (pIC₅₀ values are 6.43 and 7.14 in Ca²⁺ and cAMP assays respectively).

Technical Data

M.Wt:

986.84

Formula:

C₃₇H₂₆N₄Na₄O₁₅S₄

Solubility:

Soluble to 20 mM in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

202982-98-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

?-Nicotinamide Adenine Dinucleotide (?-NAD) Inhibits ATP-Dependent IL-1? Release from Human Monocytic Cells
SD Hiller, S Heldmann, K Richter, I Jurastow, M Küllmar, A Hecker, S Wilker, G Fuchs-Moll, I Manzini, G Schmalzing, W Kummer, W Padberg, JM McIntosh, J Damm, A Zakrzewicz, V Grau
Int J Mol Sci, 2018;19(4):.
NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk
Meis et al.
J.Pharmacol.Exp.Ther., 2010;332:238

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Citations for NF 340

The citations listed below are publications that use Tocris products. Selected citations for NF 340 include:

7 Citations: Showing 1 - 7

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death.
Authors: Dreisig Et al.
Front Immunol 2018;9:1159
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells.
Authors: Ng
Cell Signal 2018;51:59
Anti-Depressant Flu Reveals its Therapeutic Effect Via Astrocytes.
Authors: Kinoshita Et al.
EBioMedicine 2018;32:72
Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense.
Authors: Ledderose Et al.
J Infect Dis 2016;213:456
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
Authors: Nishimura Et al.
PLoS Pathog 2015;11:e1005184
Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
Authors: Barragán-Iglesias Et al.
Mol Pain 2014;10:29
The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
Authors: Gao Et al.
Autophagy 2013;9:31

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