hh NF 340 (CAS 202982-98-7): R&D Systems
Catalog Number: 3830
Chemical Name: 4,4'-(Carbonylbis(imino-3,1-(4-methyl-phenylene)carbonylimino))bis(naphthalene-2,6-disulfonic acid) tetrasodium salt
Biological Activity
P2Y11 antagonist; exhibits 520-fold selectivity for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6 and P2Y12 receptors. Displays competitive antagonism against ATPγS (pIC50 values are 6.43 and 7.14 in Ca2+ and cAMP assays respectively).
Technical Data
  • M.Wt:
    986.84
  • Formula:
    C37H26N4Na4O15S4
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    202982-98-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. NF546 [4,4'-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-γ,γ'-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleuk
    Meis et al.
    J.Pharmacol.Exp.Ther., 2010;332:238
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NF 340 include:

2 Citations: Showing 1 - 2
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  1. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
    Authors: Barragán-Iglesias Et al.
    Mol Pain 2014;10:29
  2. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells.
    Authors: Gao Et al.
    Autophagy 2013;9:31

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