Catalog Number: 0236
Chemical Name: (±)-3-Piperidine carboxylic acid
Biological Activity
GABA uptake inhibitor. IC50 values are 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.
Technical Data
  • M.Wt:
    129.16
  • Formula:
    C6H11NO2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    60252-41-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tiagabine, SK&F 89976-A, CI 966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
    Borden et al.
    Eur.J.Pharmacol., 1994;269:219
  2. GABA agonists, antagonists and uptake inhibitors. Design and therapeutic aspects.
    Krogsgaard-Larsen et al.
    J.Med.Chem., 1981;24:1377
  3. Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA binding.
    Schousboe et al.
    J.Neurochem., 1979;33:181
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-Nipecotic acid include:

1 Citations: Showing 1 - 1

  1. GABAergic signalling in a neurogenic niche of the turtle spinal cord.
    Authors: Reali Et al.
    J Physiol 2011;589:5633

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