NKX2.2 Antibody (SPM564) - IHC-Prediluted

Novus Biologicals | Catalog # NBP2-45155

Novus Biologicals

Key Product Details

Species Reactivity

Human, Mouse, Rat, Chicken

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # SPM564

Format

IHC-Prediluted
View all NKX2.2 Primary Antibodies »

Product Specifications

Immunogen

Human NKX2.2 recombinant protein (Uniprot: O95096)

Localization

Nuclear

Marker

Neuroendocrine & Ewing Sarcoma Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.

Scientific Data Images for NKX2.2 Antibody (SPM564) - IHC-Prediluted

Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155]

Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155]

Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155] - Formalin-paraffin Ewings sarcoma stained with NKX2.2 MAb (SPM564).
Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155]

Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155]

Immunohistochemistry-Paraffin: NKX2.2 Antibody (SPM564) - IHC-Prediluted [NBP2-45155] - Formalin-fixed, paraffin-embedded human pancreas stained with NKX2.2 Monoclonal Antibody (SPM564).

Applications for NKX2.2 Antibody (SPM564) - IHC-Prediluted

Application
Recommended Usage

Immunohistochemistry-Paraffin

0.5 - 1.0 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Format

IHC-Prediluted

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: NKX2.2

Nkx2.2, or Homeobox protein Nkx-2.2, consists of a 273 amino acid isoform that is 30 kDa, and is involved in controlling and maintaining the expression of genes within pancreatic endocrine cells and axons. Current research is being conducted on the relationship between Nkx2.2 and a variety of diseases and disorders, including glioma, neuronitis, maturity-onset diabetes, pancreatitis, Partington syndrome, sarcoma, gastrointestinal neuroendocrine tumor, acute lymphoblastic leukemia, multiple sclerosis, and carcinoid tumors. The protein has been linked to the Wnt, Hedgehog, and notch pathways, as well as regulation of beta-cell development and gene expression. NKx2.2 interacts with several other proteins, including OLIG2, HDAC1, SIN3A, FOXA2, and FOXO1.

Long Name

NK2 Homeobox 2

Alternate Names

NKX2B

Gene Symbol

NKX2-2

Additional NKX2.2 Products

Product Documents for NKX2.2 Antibody (SPM564) - IHC-Prediluted

Certificate of Analysis

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Product Specific Notices for NKX2.2 Antibody (SPM564) - IHC-Prediluted

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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