Catalog Number: 1358
Biological Activity
Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Lys-13 = C-terminal amide)

  • Solubility:
    Soluble to 0.67 mg/ml in 20% acetonitrile
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacology of nociceptin and its receptor: a novel therapeutic target.
    Calo et al.
    Br.J.Pharmacol., 2000;129:1261
  2. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships.
    Varani et al.
    Br.J.Pharmacol., 1998;125:1485

The citations listed below are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:

1 Citations: Showing 1 - 1

  1. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
    Authors: Kuzmin Et al.
    Br J Pharmacol 2004;141:132

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Order Details

    1358 has been discontinued.

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