Nociceptin (1-13)NH2
Biological Activity
Bioactive metabolite of nociceptin and potent agonist for the ORL1 receptor (pEC50 = 7.9 in mouse vas deferens, Ki = 0.75 nM for binding to rat forebrain membranes).Technical Data
(Modifications: Lys-13 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacology of nociceptin and its receptor: a novel therapeutic target.
Calo et al.
Br.J.Pharmacol., 2000;129:1261 -
Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships.
Varani et al.
Br.J.Pharmacol., 1998;125:1485
Product Datasheets
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Citation for Nociceptin (1-13)NH2
The citations listed below are publications that use Tocris products. Selected citations for Nociceptin (1-13)NH2 include:
1 Citation: Showing 1 - 1
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Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
Authors: Kuzmin Et al.
Br J Pharmacol 2004;141:132
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