Catalog Number: 1118
Biological Activity
An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 2 mg/ml in PBS
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways.
    Fantin et al.
    Br.J.Pharmacol., 2007;152:549
  2. Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.
    Nicol et al.
    Eur.J.Pharmacol., 1998;356:R1
  3. Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test.
    Yamamoto et al.
    Neurosci.Lett., 1999;262:179
  4. Nocistatin, a peptide that blocks nociceptin action in pain transmission.
    Okuda-Ashitaka et al.
    Nature, 1998;392:286

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