An endogenous peptide derived from the same precursor as nociceptin, which is able to block nociceptin-induced allodynia and hyperalgesia and may play an opposing role in pain transmission. Shown to reverse nociceptin inhibition of glutamate release from rat brain slices; also modulates 5-HT transmission in the mouse neocortex via mechanisms separate from nociceptin/orphanin FQ.
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Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways.
Fantin et al.
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.
Nicol et al.
Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test.
Yamamoto et al.
Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Okuda-Ashitaka et al.