Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
Biological ActivityEndogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor.
Duncan et al.
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Hanus et al.
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor.
Sugiura et al.
Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues.
Suhara et al.
Citation for Noladin ether
The citations listed below are publications that use Tocris products. Selected citations for Noladin ether include:
1 Citation: Showing 1 - 1
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Authors: Ho and Randall
PLoS One 2007;150:641
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