Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
Biological ActivityNoladin ether is an endogenous agonist for the GPR55 and CB1 receptors (EC50 values are 10 and 37 nM respectively) that displays selectivity over CB2 receptors (Ki values are 21.2 nM and > 3mM at CB1 and CB2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo. Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 Gi/o linked receptor.
Duncan et al.
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor.
Hanus et al.
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor.
Sugiura et al.
Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, and its metabolically stable ether-linked analogues.
Suhara et al.
Citation for Noladin ether
The citations listed below are publications that use Tocris products. Selected citations for Noladin ether include:
1 Citation: Showing 1 - 1
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Authors: Ho and Randall
PLoS One 2007;150:641
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