Chemical Name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[18.104.22.168,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
Biological ActivityMonovalent cation ionophore that displays selectivity for K+ and NH4+ (K+ = NH4+ > Na+ > Mg2+ > Li+ >> Ca2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4'O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells.
Borrel et al.
Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid.
Woo et al.
Antimicrob.Agents Chemother., 1999;43:1662
Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane.
Garcia et al.
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