Home / Kappa Opioid Receptor Antagonists / nor-Binaltorphimine dihydrochloride

nor-Binaltorphimine dihydrochloride

0347 30 Citations 3 Reviews Datasheet / COA / SDS
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nor-Binaltorphimine dihydrochloride | CAS No. 113158-34-2 | Kappa Opioid Receptor Antagonists
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Description: Selective κ antagonist
Alternative Names: nor-BNI, Norbinaltorphimine

Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride

Purity: ≥98%

Product Details
Citations (30)
Supplemental Products
Reviews (3)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

A selective κ-opioid receptor antagonist.

Technical Data

M.Wt:
734.72
Formula:
C40H43N3O6.2HCl
Solubility:
Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
113158-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the University of Minnesota

Product Datasheets

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Citations for nor-Binaltorphimine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for nor-Binaltorphimine dihydrochloride include:

30 Citations: Showing 1 - 10

  1. The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrain-projections from the insular cortex.
    Authors: Pina Et al.
    Neuropharmacology  2020;165:107831
  2. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
    Authors: Telpoukhovskaia Et al.
    Sci Rep  2020;10
  3. The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions.
    Authors: Norris Et al.
    Sci Rep  2019;9:9760
  4. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  5. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress.
    Authors: Polter
    Elife  2017;6:e23785
  6. Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice.
    Authors: Smith Et al.
    Proc Natl Acad Sci U S A  2016;113:13893
  7. Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats.
    Authors: Chen Et al.
    PLoS One  2015;7:4877
  8. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
    Authors: Lee and Ko
    Neuropsychopharmacology  2015;5:11676
  9. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Appl Environ Microbiol  2015;22:49
  10. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
    Endocrinology  2015;156:576
  11. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Sci Rep  2015;10:e0145556
  12. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor.
    Authors: Ma Et al.
    Cell Death Dis  2014;5:e1099
  13. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
    Authors: Kuzmin Et al.
    Transl Psychiatry  2013;3:e310
  14. Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
    Authors: Tejeda Et al.
    Neuropsychopharmacology  2013;38:1770
  15. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Br J Cancer  2013;38:1296
  16. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
    Authors: Schmid Et al.
    J Biol Chem  2013;288:22387
  17. Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.
    Authors: Morse Et al.
    BMC Pharmacol Toxicol  2013;14:17
  18. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
    Authors: Guida Et al.
    Mol Pain  2012;8:60
  19. Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
    Authors: Rogala Et al.
    PLoS One  2012;7:e49669
  20. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
    Neuropsychopharmacology  2012;7:e44344
  21. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
    Authors: Kuzumaki Et al.
    Neuropsychopharmacology  2012;106:1148
  22. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  23. κ opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.
    Authors: Russell-Randall and Dortch-Carnes
    J Biomed Sci  2011;52:5233
  24. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol  2010;80:1478
  25. Antidepressant-like effects of κ-opioid receptor antagonists in Wistar Kyoto rats.
    Authors: Carr Et al.
    Invest Ophthalmol Vis Sci  2010;35:752
  26. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  27. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    PLoS One  2009;2011:159209
  28. Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.
    Authors: Braida Et al.
    Br J Pharmacol  2009;157:844
  29. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci  2008;28:407
  30. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Int J Clin Exp Med  2007;32:399

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VersaClone cDNA Plasmids

Human KOR (NP_000903) VersaClone cDNA

RDC0145

Rat KOR (NP_058863) VersaClone cDNA

RDC0433

Reviews for nor-Binaltorphimine dihydrochloride

Average Rating: 5 (Based on 3 Reviews)

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JNK-dependent rescue of LTPGABA by acute norBNI
By Anonymous on 03/18/2020
Application: Species: Rat

100nM

PMID: 28402252
Reliable compound
By Anonymous on 11/25/2019
Application: Species: Human

Successfully stopped selective agonist-induced ERK phosphorylation in CHO cells. It’s a very reliable compound.

Good product
By Anonymous on 05/14/2019
Application: Species: Mouse

Effectively blocked agonist-induced reductions in neuronal firing in slice. Works as advertised & would recommend.

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