Catalog Number: 0347
Alternate Names: nor-BNI, Norbinaltorphimine
Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride
Biological Activity
A selective κ-opioid receptor antagonist.
Technical Data
  • M.Wt:
    734.72
  • Formula:
    C40H43N3O6.2HCl
  • Solubility:
    Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    113158-34-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota
Background References
  1. Differential agonist regulation of the human κ-opioid receptor.
    Blake et al.
    J.Neurochem., 1997;68:1846
  2. Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats.
    Feng et al.
    J.Pharmacol.Exp.Ther., 1997;283:932
  3. Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor.
    Portoghese et al.
    J.Med.Chem., 1994;37:1495
Citations:

The citations listed below are publications that use Tocris products. Selected citations for nor-Binaltorphimine dihydrochloride include:

21 Citations: Showing 1 - 10
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  1. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress.
    Authors: Polter
    Elife 2017;6:e23785
  2. Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats.
    Authors: Chen Et al.
    PLoS One 2015;7:4877
  3. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
    Authors: Lee and Ko
    Neuropsychopharmacology 2015;5:11676
  4. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Appl Environ Microbiol 2015;22:49
  5. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
    Endocrinology 2015;156:576
  6. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Sci Rep 2015;10:e0145556
  7. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor.
    Authors: Ma Et al.
    Cell Death Dis 2014;5:e1099
  8. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
    Authors: Kuzmin Et al.
    Transl Psychiatry 2013;3:e310
  9. Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
    Authors: Tejeda Et al.
    Neuropsychopharmacology 2013;38:1770
  10. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Br J Cancer 2013;38:1296
  11. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
    Authors: Schmid Et al.
    J Biol Chem 2013;288:22387
  12. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
    Authors: Guida Et al.
    Mol Pain 2012;8:60
  13. Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
    Authors: Rogala Et al.
    PLoS One 2012;7:e49669
  14. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
    Neuropsychopharmacology 2012;7:e44344
  15. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
    Authors: Kuzumaki Et al.
    Neuropsychopharmacology 2012;106:1148
  16. κ opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.
    Authors: Russell-Randall and Dortch-Carnes
    J Biomed Sci 2011;52:5233
  17. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol 2010;80:1478
  18. Antidepressant-like effects of κ-opioid receptor antagonists in Wistar Kyoto rats.
    Authors: Carr Et al.
    Invest Ophthalmol Vis Sci 2010;35:752
  19. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    PLoS One 2009;2011:159209
  20. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci 2008;28:407
  21. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Int J Clin Exp Med 2007;32:399
Expand to show all 21 Citations

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