nor-Binaltorphimine dihydrochloride

  ( 23 citations )    
Product Datasheet
Catalog Number:0347
Alternate Names:nor-BNI, Norbinaltorphimine
Chemical Name:17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride
Product Details
Citations (23)
Supplemental Products
Biological Activity
A selective κ-opioid receptor antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota
Product Datasheets
COA view current batch
or select another batch:

The citations listed below are publications that use Tocris products. Selected citations for nor-Binaltorphimine dihydrochloride include:

23 Citations: Showing 1 - 10
Filter your results:

  1. Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress.
    Authors: Polter
    Elife  2017;6:e23785
  2. Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats.
    Authors: Chen Et al.
    PLoS One  2015;7:4877
  3. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
    Authors: Lee and Ko
    Neuropsychopharmacology  2015;5:11676
  4. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Appl Environ Microbiol  2015;22:49
  5. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
    Endocrinology  2015;156:576
  6. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Sci Rep  2015;10:e0145556
  7. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor.
    Authors: Ma Et al.
    Cell Death Dis  2014;5:e1099
  8. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
    Authors: Kuzmin Et al.
    Transl Psychiatry  2013;3:e310
  9. Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
    Authors: Tejeda Et al.
    Neuropsychopharmacology  2013;38:1770
  10. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Br J Cancer  2013;38:1296
  11. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
    Authors: Schmid Et al.
    J Biol Chem  2013;288:22387
  12. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
    Authors: Guida Et al.
    Mol Pain  2012;8:60
  13. Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
    Authors: Rogala Et al.
    PLoS One  2012;7:e49669
  14. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
    Neuropsychopharmacology  2012;7:e44344
  15. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
    Authors: Kuzumaki Et al.
    Neuropsychopharmacology  2012;106:1148
  16. Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.
    Authors: Morse Et al.
    PLoS One  2011;6:e25643
  17. κ opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.
    Authors: Russell-Randall and Dortch-Carnes
    J Biomed Sci  2011;52:5233
  18. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol  2010;80:1478
  19. Antidepressant-like effects of κ-opioid receptor antagonists in Wistar Kyoto rats.
    Authors: Carr Et al.
    Invest Ophthalmol Vis Sci  2010;35:752
  20. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
    Authors: Gross Et al.
    Am J Physiol Heart Circ Physiol  2010;298:H2201
  21. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    PLoS One  2009;2011:159209
  22. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci  2008;28:407
  23. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Int J Clin Exp Med  2007;32:399
Expand to show all Citations


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used nor-Binaltorphimine dihydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order


Customer Information

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee