Catalog Number: 0347
Alternate Names: nor-BNI, Norbinaltorphimine
Chemical Name: 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride
Biological Activity
A selective κ-opioid receptor antagonist.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the University of Minnesota
Background References
  1. Differential agonist regulation of the human κ-opioid receptor.
    Blake et al.
    J.Neurochem., 1997;68:1846
  2. Nor-binaltorphimine precipitates withdrawal and excitatory amino acid release in the locus ceruleus of butorphanol- but not morphine-dependent rats.
    Feng et al.
    J.Pharmacol.Exp.Ther., 1997;283:932
  3. Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17'-basic group in the interaction with a putative address subsite on the κ opioid receptor.
    Portoghese et al.
    J.Med.Chem., 1994;37:1495

The citations listed below are publications that use Tocris products. Selected citations for nor-Binaltorphimine dihydrochloride include:

Showing Results 1 - 10 of 20

  1. Effect of adenoviral delivery of prodynorphin gene on experimental inflammatory pain induced by formalin in rats.
    Authors: Chen Et al.
    PLoS One
  2. Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
    Authors: Lee and Ko
  3. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions.
    Authors: Yi Et al.
    Appl Environ Microbiol
  4. Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
    Authors: Ruiz-Pino Et al.
  5. Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
    Authors: Chen Et al.
    Sci Rep
  6. Methamphetamine induces autophagy as a pro-survival response against apoptotic endothelial cell death through the Kappa opioid receptor.
    Authors: Ma Et al.
    Cell Death Dis
  7. Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.
    Authors: Kuzmin Et al.
    Transl Psychiatry
  8. Prefrontal cortical kappa-opioid receptor modulation of local neurotransmission and conditioned place aversion.
    Authors: Tejeda Et al.
  9. Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
    Authors: Romero-Picó Et al.
    Br J Cancer
  10. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons.
    Authors: Schmid Et al.
    J Biol Chem
  11. Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
    Authors: Guida Et al.
    Mol Pain
  12. Effects of a post-shock injection of the kappa opioid receptor antagonist norbinaltorphimine (norBNI) on fear and anxiety in rats.
    Authors: Rogala Et al.
    PLoS One
  13. GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats.
    Authors: Grachev Et al.
  14. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.
    Authors: Kuzumaki Et al.
  15. κ opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber.
    Authors: Russell-Randall and Dortch-Carnes
    J Biomed Sci
  16. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol
  17. Antidepressant-like effects of κ-opioid receptor antagonists in Wistar Kyoto rats.
    Authors: Carr Et al.
    Invest Ophthalmol Vis Sci
  18. Endogenous opiates in the nucleus tractus solitarius mediate electroacupuncture-induced sleep activities in rats.
    Authors: Cheng Et al.
    PLoS One
  19. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system.
    Authors: Land Et al.
    J Neurosci
  20. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Int J Clin Exp Med
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