nor-Binaltorphimine dihydrochloride

Tocris Bioscience | Catalog # 0347

Selective κ antagonist
Tocris Bioscience
Discontinued Product
0347 has been discontinued. View all Kappa Opioid Receptor Antagonists products.

Key Product Details

Description

Selective κ antagonist

Alternative Names

nor-BNI,Norbinaltorphimine
View all Kappa Opioid Receptor Antagonists »

Product Description

nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist.

Licensing Information

Sold with the permission of the University of Minnesota

Product Specifications for nor-Binaltorphimine dihydrochloride

Molecular Weight

734.72

Formula

C40H43N3O6.2HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride

CAS Number

113158-34-2

PubChem ID

11957626

InChI Key

JOJPJLHRMGPDPV-LZQROVCBSA-N

SMILES

Cl.Cl.OC1=CC=C2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](OC1=C24)C1=C(C[C@@]35O)C2=C(N1)[C@@H]1OC3=C(O)C=CC4=C3[C@@]11CCN(CC3CC3)[C@H](C4)[C@]1(O)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 18.37 25 with gentle warming
DMSO 18.37 25

Preparing Stock Solutions for nor-Binaltorphimine dihydrochloride

The following data is based on the product molecular weight 734.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.44 mL 27.22 mL 54.44 mL
1.25 mM 1.09 mL 5.44 mL 10.89 mL
2.5 mM 0.54 mL 2.72 mL 5.44 mL
12.5 mM 0.11 mL 0.54 mL 1.09 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for nor-Binaltorphimine dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for nor-Binaltorphimine dihydrochloride

For research use only

Citations for nor-Binaltorphimine dihydrochloride

Customer Reviews for nor-Binaltorphimine dihydrochloride (3)

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3 Customer Ratings
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  • JNK-dependent rescue of LTPGABA by acute norBNI
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Cell Line/Tissue: brain
    Verified Customer | Posted 03/18/2020
    100nM
    nor-Binaltorphimine dihydrochloride 0347
  • Reliable compound
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 11/25/2019
    Successfully stopped selective agonist-induced ERK phosphorylation in CHO cells. It’s a very reliable compound.
    nor-Binaltorphimine dihydrochloride 0347
  • Good product
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 05/14/2019
    Effectively blocked agonist-induced reductions in neuronal firing in slice. Works as advertised & would recommend.
    nor-Binaltorphimine dihydrochloride 0347

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