Catalog Number: 1308
Biological Activity
Selective and competitive nociceptin receptor antagonist, devoid of any agonist activity. Binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Gly-1 = N-Bn-Gly, Lys-13 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 10% acetonitrile
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of [Nphe1]nociceptin(1-13)NH2, a new selective nociceptin receptor antagonist.
    Calo et al.
    Br.J.Pharmacol., 2000;129:1183
  2. Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.
    Hashimoto et al.
    Neurosci.Lett., 2000;278:109
  3. [Nphe1]nociceptin-(1-13)NH2 selectively antagonizes nociceptin effects in the rabbit isolated ileum.
    Pheng et al.
    Eur.J.Pharmacol., 2000;397:383
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