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NPS ALX Compound 4a dihydrochloride

3285 Datasheet / COA / SDS
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3285/10
3285/50
NPS ALX Compound 4a dihydrochloride | CAS No. 1781934-44-8 | 5-HT6 Receptor Antagonists
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Description: Potent and selective 5-HT6 antagonist

Chemical Name: 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride

Purity: ≥99%

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Biological Activity

Potent and competitive 5-HT6 antagonist (IC50 = 7.2 nM, Ki = 0.2 nM) that displays selectivity over other 5-HT and D2 receptors.

Technical Data

M.Wt:
504.47
Formula:
C25H25N3O2S.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
1781934-44-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists.
    Isaac et al.
    Bioorg.Med.Chem.Letts., 2000;10:1719

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VersaClone cDNA Plasmids

Human 5-HT6 (NP_000862) VersaClone cDNA

RDC0250

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