Catalog Number: 4517
Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Biological Activity
Potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.
    von Wantoch Rekowski et al.
    Bioorg.Med.Chem., 2010;18:1288
  2. The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.
    Morbidelli et al.
    Am.J.Physiol.Regul.Integr.Comp.Physiol., 2010;298:R824
  3. Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
    Olesen et al.
    Br.J.Pharmacol., 1998;123:299
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