Potent soluble guanylyl cyclase (sGC) inhibitor (Ki
= 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50
values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
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Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.
von Wantoch Rekowski et al.
The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.
Morbidelli et al.
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
Olesen et al.