Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Biological ActivitySelective non-competitive kainate receptor antagonist; displays selectivity for GluK1 (formerly GLUK5) subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GluK1 (formerly GLUK5) and GluK2 (formerly GLUK6) receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.
Christensen et al.
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NS 3763 performed extremely well when tested for NMDA activity. The correlation of NS 3763 was studied in respect to its effect with NMDA regulation.