Selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5
subunit-containing receptors (IC50
values are 1.6 and > 30 μ
M for homomeric GLUK5
receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50
> 30 μ
Soluble to 25 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.
Christensen et al.