Catalog Number: 2187
Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid
Biological Activity
Selective non-competitive kainate receptor antagonist; displays selectivity for GLUK5 subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).
Technical Data
  • M.Wt:
    404.38
  • Formula:
    C22H16N2O6
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    70553-45-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro characterization of 5-carboxyl-2,4-di-benzamido-benzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors.
    Christensen et al.
    J.Pharmacol.Exp.Ther., 2004;309:1003

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