NS 3763

Catalog # Availability Size / Price Qty
2187/10
2187/50
NS 3763 | CAS No. 70553-45-6 | Kainate Receptor Antagonists
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Description: GluK1 selective and non-competitive kainate antagonist

Chemical Name: 4,6-Bis(benzoylamino)-1,3-benzenedicarboxylic acid

Purity: ≥98%

Product Details
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Reviews (1)

Biological Activity

Selective non-competitive kainate receptor antagonist; displays selectivity for GluK1 (formerly GLUK5) subunit-containing receptors (IC50 values are 1.6 and > 30 μM for homomeric GluK1 (formerly GLUK5) and GluK2 (formerly GLUK6) receptors respectively). Has minimal activity at AMPA and NMDA receptors (IC50> 30 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
404.38
Formula:
C22H16N2O6
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
70553-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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NS 3763 was studied to determine its NMDA effect:Product works well and the results publishable
By Sadequl Islam on 10/12/2018
Species: Human

NS 3763 performed extremely well when tested for NMDA activity. The correlation of NS 3763 was studied in respect to its effect with NMDA regulation.


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