NSC 23766

  ( 43 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2161
Chemical Name:N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
Product Details
Citations (43)
Reviews
Biological Activity
Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotyes in prostate cancer cells.
Technical Data
  • M.Wt:
    530.97
  • Formula:
    C24H35N7.3HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    1177865-17-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NSC 23766 include:

43 Citations: Showing 1 - 10
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  1. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
    Authors: Benedicto
    Nat Commun  2017;8:15374
  2. The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice.
    Authors: Chang Et al.
    Virulence  2016;7:806
  3. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling.
    Authors: Abedini Et al.
    FASEB J  2016;30:1534
  4. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.
    Authors: Cosgrove
    Nature Materials  2016;15:1297
  5. Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory.
    Authors: Gao Et al.
    Stem Cell Res Ther  2015;8:65
  6. Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.
    Authors: Kassmer Et al.
    Nat Commun  2015;6:8565
  7. Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway.
    Authors: Yang Et al.
    Proc Natl Acad Sci U S A  2015;6:250
  8. Endothelial Rac1 is essential for hematogenous metastasis to the lung.
    Authors: Yao Et al.
    Sci Rep  2015;6:17501
  9. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex.
    Authors: Alves Et al.
    Front Mol Neurosci  2015;5:14534
  10. proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons.
    Authors: Gibon Et al.
    J Neurosci  2015;35:9741
  11. EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells.
    Authors: Chun and Shim
    Oncotarget  2015;23:539
  12. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization.
    Authors: Lomakin Et al.
    Nat Cell Biol  2015;17:1435
  13. Architecture and migration of an epithelium on a cylindrical wire.
    Authors: Yevick Et al.
    Nat Commun  2015;112:5944
  14. Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy.
    Authors: Cabet Et al.
    PLoS One  2015;10:e0137009
  15. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition.
    Authors: Serra Et al.
    PLoS One  2015;10:e0133875
  16. Gasdermin-B promotes invasion and metastasis in breast cancer cells.
    Authors: Hergueta-Redondo Et al.
    PLoS One  2014;9:e90099
  17. Coxsackievirus A9 infects cells via nonacidic multivesicular bodies.
    Authors: Huttunen Et al.
    J Virol  2014;88:5138
  18. Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells.
    Authors: Chen Et al.
    J Biol Chem  2014;5:4406
  19. The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function.
    Authors: Hou Et al.
    J Neurosci  2014;34:14006
  20. Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion.
    Authors: Uotila Et al.
    J Cell Biol  2014;289:32230
  21. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
    Authors: McNary Et al.
    Tissue Eng Part A  2014;20:921
  22. CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa.
    Authors: Lichius Et al.
    J Cell Sci  2014;127:1953
  23. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
    Authors: Kenny Et al.
    J Clin Invest  2014;124:4614
  24. Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies.
    Authors: Prowse Et al.
    PLoS One  2013;8:e58898
  25. Rac1 and Cdc42 GTPases regulate shear stress-driven β-catenin signaling in osteoblasts.
    Authors: Wan Et al.
    Biochem Biophys Res Commun  2013;433:502
  26. PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
    Authors: Zhu and Nelson
    Cancer Res  2013;379:235
  27. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion.
    Authors: Moore Et al.
    Development  2013;140:4763
  28. LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells.
    Authors: Harrison Et al.
    BMC Cancer  2013;13:501
  29. Involvement of Botrytis cinerea small GTPases BcRAS1 and BcRAC in differentiation, virulence, and the cell cycle.
    Authors: Dub Et al.
    Eukaryot Cell  2013;12:1609
  30. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
    Authors: Martin Et al.
    J Clin Invest  2013;123:4449
  31. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.
    Authors: Farrow Et al.
    Proc Natl Acad Sci U S A  2013;110:18674
  32. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo.
    Authors: Zhu Et al.
    Ann Rheum Dis  2013;
  33. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior.
    Authors: Tseng Et al.
    Oncotarget  2012;9:1113
  34. Inhibition of hepcidin transcription by growth factors.
    Authors: Goodnough Et al.
    Hepatology  2012;56:291
  35. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.
    Authors: Akhmetshina Et al.
    Biomol Ther (Seoul)  2012;3:735
  36. ROCK1 feedback regulation of the upstream small GTPase RhoA.
    Authors: Tang Et al.
    Cell Signal  2012;24:1375
  37. Cadherin point mutations alter cell sorting and modulate GTPase signaling.
    Authors: Tabdili Et al.
    J Cell Sci  2012;125:3299
  38. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways.
    Authors: Gulhati Et al.
    J Transl Med  2011;71:3246
  39. TCR-induced activation of LFA-1 involves signaling through Tiam1.
    Authors: Grönholm Et al.
    J Immunol  2011;187:3613
  40. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque.
    Authors: Dwivedi Et al.
    Sci Rep  2010;8:128
  41. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    Nat Methods  2010;110:44
  42. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation.
    Authors: Rex Et al.
    Dev Biol  2009;186:85
  43. Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine.
    Authors: Brown and Price
    Vet Microbiol  2007;120:328
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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