NSC 23766

Tocris Bioscience | Catalog # 2161

Selective inhibitor of Rac1-GEF interaction; antioncogenic
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of Rac1-GEF interaction; antioncogenic
View all Rho GTPase Inhibitors »

Product Description

NSC 23766 is a selective inhibitor of Rac1-GEF interaction. NSC 23766 prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. The compound inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotypes in prostate cancer cells. NSC 23766 also inhibits mammary carcinoma cell invasion in vitro and inhibits mammary tumor progression and metastasis in a mouse model.

Product Specifications for NSC 23766

Molecular Weight

530.97

Formula

C24H35N7.3HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride

CAS Number

1177865-17-6

PubChem ID

16759159

InChI Key

CPUHORIUXPQCHW-UHFFFAOYSA-N

SMILES

Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(C)=CC(NC2=CC=C3N=C(C)C=C(N)C3=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 53.1 100
DMSO 53.1 100

Preparing Stock Solutions for NSC 23766

The following data is based on the product molecular weight 530.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.88 mL 9.42 mL 18.83 mL
5 mM 0.38 mL 1.88 mL 3.77 mL
10 mM 0.19 mL 0.94 mL 1.88 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 342 publications citing the usage of this product.

Product Documents for NSC 23766

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NSC 23766

For research use only

Customer Reviews for NSC 23766 (2)

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  • Rac1 inhibitor
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 09/08/2025
    Small GTPase Activity and Inhibitors We analyzed the activity of small GTPases in the BMDMs and Raw264.7 cells by using the recommended procedure provided with the G-LISA Assay Biochem kit (Cytoskeleton Inc.). The activities of RhoA (BK124), Rac (BK125), and Cdc42 (BK127) were assessed. For the pharmacological inhibition study, GFP-mNinj1 Raw264.7 cells were treated with either NSC23766 (Rac1 inhibitor, Tocris) or the dimethyl sulfoxide carrier for 3 h at the indicated concentrations.
  • Specific rac inhibitor
    Name: Anonymous
    Species: Bovine
    Assay Type: In Vitro
    Verified Customer | Posted 03/26/2018
    Rac specific inhibitor
    NSC 23766 2161

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