Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone
Biological ActivityNovel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064.
Bowman et al.
Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Griffin et al.
Potentiation of temozol. and topo. growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.
Delaney et al.
Citation for NU 1025
The citations listed below are publications that use Tocris products. Selected citations for NU 1025 include:
1 Citation: Showing 1 - 1
Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors.
Authors: Sultana Et al.
Int J Cancer 2012;131:2433
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