NU 7026

  ( 13 citations )    
Product Datasheet
Catalog Number:2828
Chemical Name:2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Product Details
Citations (13)
Reviews
Biological Activity
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
Technical Data
  • M.Wt:
    281.31
  • Formula:
    C17H15NO3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    154447-35-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NU 7026 include:

13 Citations: Showing 1 - 10
Filter your results:

  1. Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
    Authors: Nakahara Et al.
    Chembiochem  2015;89:5040
  2. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
    Authors: Allen Et al.
    Front Oncol  2015;5:260
  3. Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
    Authors: You Et al.
    Elife  2015;4
  4. Spatio-temporal regulation of RAG2 following genotoxic stress.
    Authors: Rodgers Et al.
    DNA Repair (Amst)  2015;27:19
  5. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One  2015;10:e0145744
  6. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
    Authors: Yousefzadeh Et al.
    PLoS Genet  2014;10:e1004654
  7. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  8. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  9. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.
    Authors: Petruccelli Et al.
    Mol Cancer Ther  2013;12:1591
  10. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
    Authors: Ando Et al.
    Mol Cell  2012;47:681
  11. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
    Authors: Tang Et al.
    J Neurosci  2012;13:665
  12. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
    Authors: Kanai Et al.
    J Natl Cancer Inst  2012;104:42
  13. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
    Authors: Bohgaki Et al.
    PLoS Genet  2011;7:e1001381
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used NU 7026?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee