Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Biological ActivityNU 7026 is an ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-I.
Veuger et al.
Cancer Res., 2003;63:6008
Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase.
Amrein et al.
Citations for NU 7026
The citations listed below are publications that use Tocris products. Selected citations for NU 7026 include:
14 Citations: Showing 1 - 10
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Authors: Jaiswal Et al.
EMBO J 2017;36:2161
Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
Authors: Nakahara Et al.
DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
Authors: Allen Et al.
Front Oncol 2015;5:260
Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
Authors: You Et al.
Spatio-temporal regulation of RAG2 following genotoxic stress.
Authors: Rodgers Et al.
DNA Repair (Amst) 2015;27:19
DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
Authors: Dolman Et al.
PLoS One 2015;10:e0145744
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Authors: Yousefzadeh Et al.
PLoS Genet 2014;10:e1004654
Targeting XRCC1 deficiency in breast cancer for personalized therapy.
Authors: Sultana Et al.
Cancer Res 2013;73:1621
The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
Authors: Fard Et al.
Cell Cycle 2013;13:408
Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.
Authors: Petruccelli Et al.
Mol Cancer Ther 2013;12:1591
PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
Authors: Ando Et al.
Mol Cell 2012;47:681
Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
Authors: Tang Et al.
J Neurosci 2012;13:665
Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Authors: Kanai Et al.
J Natl Cancer Inst 2012;104:42
Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
Authors: Bohgaki Et al.
PLoS Genet 2011;7:e1001381
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Reviews for NU 7026
Average Rating: 5 (Based on 1 Review)
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I used the DNA-PK inhibitor (NU7026) to treat human osteosarcoma cells (U2OS) and assessed if the inhibition worked by blotting for pDNA-PKcs (S2056). The inhibitor works extremely well!