NU 7026

  ( 13 citations )    
Product Datasheet
Catalog Number:2828
Chemical Name:2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
Product Details
Citations (13)
Biological Activity
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC50 values are 0.23, 13.0, > 100 and > 100 μM for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for NU 7026 include:

13 Citations: Showing 1 - 10
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  1. Activation of NF-κB by human papillomavirus 16 E1 limits E1-dependent viral replication through degradation of E1.
    Authors: Nakahara Et al.
    Chembiochem  2015;89:5040
  2. DNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.
    Authors: Allen Et al.
    Front Oncol  2015;5:260
  3. Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
    Authors: You Et al.
    Elife  2015;4
  4. Spatio-temporal regulation of RAG2 following genotoxic stress.
    Authors: Rodgers Et al.
    DNA Repair (Amst)  2015;27:19
  5. DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
    Authors: Dolman Et al.
    PLoS One  2015;10:e0145744
  6. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
    Authors: Yousefzadeh Et al.
    PLoS Genet  2014;10:e1004654
  7. Targeting XRCC1 deficiency in breast cancer for personalized therapy.
    Authors: Sultana Et al.
    Cancer Res  2013;73:1621
  8. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway.
    Authors: Fard Et al.
    Cell Cycle  2013;13:408
  9. Expression of leukemia-associated fusion proteins increases sensitivity to histone deacetylase inhibitor-induced DNA damage and apoptosis.
    Authors: Petruccelli Et al.
    Mol Cancer Ther  2013;12:1591
  10. PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling.
    Authors: Ando Et al.
    Mol Cell  2012;47:681
  11. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor.
    Authors: Tang Et al.
    J Neurosci  2012;13:665
  12. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
    Authors: Kanai Et al.
    J Natl Cancer Inst  2012;104:42
  13. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.
    Authors: Bohgaki Et al.
    PLoS Genet  2011;7:e1001381
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