NVP BHG 712
Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate
Purity: ≥98%
Biological Activity
Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Podocyte EphB4 signaling helps recovery from glomerular injury.
Wnuk et al.
Kidney Int., 2012;81:1212 -
The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.
Martiny-Baron et al.
Angiogenesis., 2010;13:259
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Citation for NVP BHG 712
The citations listed below are publications that use Tocris products. Selected citations for NVP BHG 712 include:
1 Citation: Showing 1 - 1
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Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos.
Authors: Krupke Et al.
Elife 2016;5
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