Catalog Number: 4405
Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide trifluoroacetate
Biological Activity
Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active.
Technical Data
  • M.Wt:
    617.5
  • Formula:
    C26H20F3N7O.CF3CO2H
  • Solubility:
    Soluble to 40 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    940310-85-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.
    Martiny-Baron et al.
    Angiogenesis., 2010;13:259
  2. Podocyte EphB4 signaling helps recovery from glomerular injury.
    Wnuk et al.
    Kidney Int., 2012;81:1212

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