OBAA
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Biological Activity
OBAA is a potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds.
Madi et al.
Agents Actions, 1991;32:144 -
Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids.
Kohler et al.
Agents Actions, 1991;32:70 -
Phospholipase A2 inhibition by alkylbenzoyl acrylic acids.
Kohler et al.
Biochem.Pharmacol., 1992;44:805
Product Datasheets
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Citations for OBAA
The citations listed below are publications that use Tocris products. Selected citations for OBAA include:
2 Citations: Showing 1 - 2
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MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.
Authors: Kuo Et al.
Am J Physiol Heart Circ Physiol 2016;310:H71
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Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
Authors: Bianca Et al.
Nat Commun 2010;161:1835
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