Catalog Number: 0606
Chemical Name: 4-(4-Octadecylphenyl)-4-oxobutenoic acid
Biological Activity
A potent inhibitor of phospholipase A2 (IC50 = 70 nM). Reduces bronchospasm in guinea pigs in vivo.
Technical Data
  • M.Wt:
    428.65
  • Formula:
    C28H44O3
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Desiccate at +4°C
  • CAS No:
    221632-26-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Phospholipase-A2 inhibition by alkylbenzoyl acrylic acids.
    Kohler et al.
    Agents Actions, 1991;32:70
  2. Phospholipase A2 inhibition by alkylbenzoyl acrylic acids.
    Kohler et al.
    Biochem.Pharmacol., 1992;44:805
  3. Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds.
    Madi et al.
    Agents Actions, 1991;32:144
Citations:

The citations listed below are publications that use Tocris products. Selected citations for OBAA include:

1 Citations: Showing 1 - 1

  1. Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
    Authors: Bianca Et al.
    Nat Commun 2010;161:1835

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