Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Biological ActivityOchratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Mechanism of action of ochratoxin A.
Dirheimer and Creppy
IARC Sci.Publ., 1991;115:171
Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
Gekle et al.
Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro.
Chong and Rahimtula
Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation.
Omar et al.
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