Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
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Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro.
Chong and Rahimtula
Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
Gekle et al.
Mechanism of action of ochratoxin A.
Dirheimer and Creppy
IARC Sci.Publ., 1991;115:171
Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation.
Omar et al.