Ochratoxin A
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Purity: ≥99%
Biological Activity
Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Mechanism of action of ochratoxin A.
Dirheimer and Creppy
IARC Sci.Publ., 1991;115:171 -
Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
Gekle et al.
J.Pharmacol.Exp.Ther., 2000;293:837 -
Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro.
Chong and Rahimtula
Biochem.Pharmacol., 1992;44:1401 -
Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation.
Omar et al.
J.Biochem.Toxicol., 1991;6:203
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