Catalog Number: 1291
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Biological Activity
Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
Technical Data
  • M.Wt:
    403.82
  • Formula:
    C20H18ClNO6
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    303-47-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro.
    Chong and Rahimtula
    Biochem.Pharmacol., 1992;44:1401
  3. Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations.
    Gekle et al.
    J.Pharmacol.Exp.Ther., 2000;293:837
  4. Mechanism of action of ochratoxin A.
    Dirheimer and Creppy
    IARC Sci.Publ., 1991;115:171
  5. Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation.
    Omar et al.
    J.Biochem.Toxicol., 1991;6:203

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