Chemical Name: cis-9-Octadecenamide
Biological ActivityEndogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors.
Hedlund et al.
Chemical characterisation of a family of brain lipids that induces sleep.
Cravatt et al.
Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.
Leggett et al.
Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors.
Huidobro-Toro and Harris
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