Endogenous sleep-inducing lipid. Acts as an agonist at the CB1
cannabinoid receptor (EC50
= 1.64 μ
M). Also appears to potentiate the actions of 5-HT on 5-HT2A
receptors, and act via an allosteric regulatory site on 5-HT7
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Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors.
Hedlund et al.
Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors.
Huidobro-Toro and Harris
Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.
Leggett et al.
Chemical characterisation of a family of brain lipids that induces sleep.
Cravatt et al.