Catalog Number: 0878
Chemical Name: cis-9-Octadecenamide
Biological Activity
Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors.
    Hedlund et al.
    Biochem.Pharmacol., 1999;58:1807
  2. Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors.
    Huidobro-Toro and Harris
    Proc.Natl.Acad.Sci.U.S.A., 1996;93:8078
  3. Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.
    Leggett et al.
    Br.J.Pharmacol., 2004;141:253
  4. Chemical characterisation of a family of brain lipids that induces sleep.
    Cravatt et al.
    Science, 1995;268:1506
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