Oleylethanolamide

Key Product Details

Product Description

Oleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC₅₀ values are 0.44, >30 and >30 μM at GPR55, CB₁ and CB₂ respectively) and PPARα agonist (EC₅₀ = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.

Product Specifications for Oleylethanolamide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Ryberg The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 2007 PMID: 17876302
• Fu Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 2003 PMID: 12955147
• Coroneos Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. J.Biol.Chem. 1995 PMID: 7559485
• de Fonseca An anorexic lipid mediator regulated by feeding. Nature 2001 PMID: 11700558
• Calignano Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur.J.Pharmacol. 2001 PMID: 11426841

Product Documents for Oleylethanolamide