Chemical Name: (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide
Biological ActivityOleylethanolamide is a lipid mediator and analog of anandamide (Cat. No. 1339) that is involved in peripheral regulation of feeding. Selective GPR55 agonist (EC50 values are 0.44, >30 and >30 μM at GPR55, CB1 and CB2 respectively) and PPARα agonist (EC50 = 120 nM). Induces satiety through activation of PPARα and is also a ceramidase inhibitor. Also endogenous agonist at the GPR119 receptor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The orphan receptor GPR55 is a novel cannabinoid receptor.
Ryberg et al.
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines.
Coroneos et al.
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.
Calignano et al.
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α.
Fu et al.
An anorexic lipid mediator regulated by feeding.
de Fonseca et al.
Citations for Oleylethanolamide
The citations listed below are publications that use Tocris products. Selected citations for Oleylethanolamide include:
4 Citations: Showing 1 - 4
Oleoylethanolamide Modulates BDNF-ERK Signaling and Neurogenesis in the Hippocampi of Rats Exposed to δ9-THC and Ethanol Binge Drinking During Adolescence.
Authors: Silva-Peña Et al.
Front Mol Neurosci 2019;12:96
Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
Authors: Suárez Et al.
Dis Model Mech 2014;7:129
Rapid non-genomic regulation of Ca2+ signals and Ins secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.
Authors: Ropero Et al.
J Endocrinol 2009;200:127
'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors.
Authors: Ho Et al.
Br J Pharmacol 2008;155:837
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