Oligodendrocyte Marker O1 Alexa Fluor® 350-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
Background: Oligodendrocyte Marker O1
Oligodendrocytes are myelinating cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. Oligodendrocyte Marker O1 recognizes a glycolipid antigen that is expressed on the surface of late oligodendrocyte progenitors. It has been commonly used in conjunction with Oligodendrocyte Marker O4 antibody to define immature oligodendrocyte (1-6). Progenitors that are O4 antigen-positive and O1 antigen-negative have been shown to differentiate into O1 antigen-positive oligodendrocytes in vitro (7).
- Schachner, M. et al. (1981) Dev. Biol. 83:328.
- Bansal, R. et al. (1989) J. Neurosci. Res. 24:548.
- Sontheimer, H. et al. (1989) Neuron 2:1135.
- Hardy, R.J. and V.L. Friedrich Jr. (1996) Development 122:2059.
- Reynolds, R. and R. Hardy (1997) J. Neurosci. Res. 47:455.
- Ono, K. et al. (1997) J. Neurosci. Res. 48:212.
- Cai, Z. et al. (2001) Brain Res. 898:126.
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