Catalog Number: 5294
Chemical Name: 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
Biological Activity
Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.
    Manandhar et al.
    Eur J Pharmacol., 2007;577:17
  2. Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
    Maher et al.
    Hepatology, 2007;46:1597
  3. Induction of drug metabolism enzymes and transporters by oltipraz in rats.
    Merrell et al.
    J.Biochem.Mol.Toxicol., 2008;22:128
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