Home / Synthetic Metalloprotease Inhibitors / ONO 4817

ONO 4817

Catalog #: 2628 Datasheet / COA / SDS

Discontinued Product

2628 has been discontinued.
View all Synthetic Metalloprotease Inhibitors products.
ONO 4817 | CAS No. 223472-31-9 | Synthetic Metalloprotease Inhibitors
1 Image
Description: Broad spectrum MMP inhibitor

Chemical Name: N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide

Purity: ≥99%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

Technical Data

M.Wt:
416.47
Formula:
C22H28N2O6
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
223472-31-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Astrocytes directly influence tumor cell invasion and metastasis in vivo.
    Wang, Ling, Cossette, Stephani, Rarick, Kevin R, Gershan, Jill, Dwinell, Michael, Harder, David R, Ramchandran, Ramani
    PLoS ONE, 2013;8(12):e80933.
  2. Excretory/secretory proteases and mechanical movement of Anisakis pegreffii infective larvae in the penetration of BALB/c mice gastrointestine
    JD Lee, LY Chung, RJ Lin, JJ Wang, HP Tu, CM Yen
    Kaohsiung J. Med. Sci., 2017;33(12):594-601.
  3. ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs.
    Yamada et al.
    Inflamm.Res., 2000;49:144
  4. Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
    Muraishi et al.
    Anticancer Res., 2001;21:3845
  5. Role of matrix metalloproteinases in intestinal inflammation.
    Medina and Radomski
    J.Pharmacol.Exp.Ther., 2006;318:933

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ONO 4817

There are currently no reviews for this product. Be the first to review ONO 4817 and earn rewards!

Have you used ONO 4817?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.