P1075
Discontinued Product
Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
Purity: ≥99%
Biological Activity
P1075 is a potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor.
Buckner et al.
Eur.J.Pharmacol., 2000;400:287 -
New windows on the mechanism of action of KATP channel openers.
Ashcroft and Gribble
TiPS, 2000;21:439 -
Stoichiometry of potassium channel opener action.
Gross et al.
Mol.Pharmacol., 1999;56:1370 -
Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator.
Higdon et al.
J.Pharmacol.Exp.Ther., 1997;280:255
Product Datasheets
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Citations for P1075
The citations listed below are publications that use Tocris products. Selected citations for P1075 include:
2 Citations: Showing 1 - 2
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KATP channel conductance of descending vasa recta pericytes.
Authors: Cao Et al.
Am J Physiol Renal Physiol 2005;289:F1235
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Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.
Authors: Baczkó Et al.
FASEB J 2005;19:980
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