Catalog Number: 1355
Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
Biological Activity
Potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).
Technical Data
  • M.Wt:
    231.3
  • Formula:
    C12H17N5
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    60559-98-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. New windows on the mechanism of action of KATP channel openers.
    Ashcroft and Gribble
    TiPS, 2000;21:439
  2. Stoichiometry of potassium channel opener action.
    Gross et al.
    Mol.Pharmacol., 1999;56:1370
  3. Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor.
    Buckner et al.
    Eur.J.Pharmacol., 2000;400:287
  4. Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator.
    Higdon et al.
    J.Pharmacol.Exp.Ther., 1997;280:255
Citations:

The citations listed below are publications that use Tocris products. Selected citations for P1075 include:

1 Citations: Showing 1 - 1

  1. Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.
    Authors: Baczkó Et al.
    FASEB J 2005;19:980

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