P1075

Catalog # Availability Size / Price Qty
1355/10
1355/50
P1075 | CAS No. 60559-98-0 | Inward Rectifier Potassium Channel Activators
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Description: Potent Kir6 (KATP) channel opener

Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

P1075 is a potent Kir6 (KATP) channel opener (EC50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd values are 17 and 3 nM respectively).

Technical Data

M.Wt:
231.3
Formula:
C12H17N5
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
60559-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for P1075

The citations listed below are publications that use Tocris products. Selected citations for P1075 include:

2 Citations: Showing 1 - 2

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P1075 was used to measure how it affects BK channel modulation
By Anonymous on 11/28/2018
Application: Species: Human

P1075 was used to measure how it affects BK channel modulation. Channel opening was assessed with non radioactive means using Rubidium efflux method.


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