) channel opener (EC50
for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (Kd
values are 17 and 3 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
New windows on the mechanism of action of KATP channel openers.
Ashcroft and Gribble
Stoichiometry of potassium channel opener action.
Gross et al.
Pharmacological and molecular analysis of ATP-sensitive K+ channels in the pig and human detrusor.
Buckner et al.
Tissue and species variation in the vascular receptor binding of 3H-P1075, a potent KATP opener vasodilator.
Higdon et al.
The citations listed below are publications that use Tocris products. Selected citations for P1075 include:
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