Catalog Number: 1460
Alternate Names: Palmityl trifluoromethyl ketone
Chemical Name: 1,1,1-Trifluoro-2-heptadecanone
Biological Activity
Phospholipase A2 inhibitor. Can also alter Ca2+ signaling in renal tubular cells.
Technical Data
  • M.Wt:
    308.43
  • Formula:
    C17H31F3O
  • Solubility:
    Soluble to 25 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    141022-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of macrophage Ca2+-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones.
    Ackermann et al.
    J.Biol.Chem., 1995;270:445
  2. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells.
    Jan et al.
    Arch.Toxicol., 2000;74:447
  3. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate.
    Lio et al.
    Biochim.Biophys.Acta, 1996;1302:55
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PACOCF3 include:

2 Citations: Showing 1 - 2
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  1. GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.
    Authors: Qiu Et al.
    J Neurosci 2014;34:13505
  2. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.
    Authors: Potapova Et al.
    J Neurosci 2013;8:e73929

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