Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all PAK6 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK6. The immunogen is located within amino acids 260 - 310 of PAK6. Amino Acid Squence: PSSSKPGPPPQSK

Specificity

PAK6 antibody is predicted to not cross-react with other PAK family proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PAK6 Antibody - BSA Free

Western Blot: PAK6 AntibodyBSA Free [NBP1-76632]

Western Blot: PAK6 AntibodyBSA Free [NBP1-76632]

Western Blot: PAK6 Antibody [NBP1-76632] - Raji lysate with PAK6 antibody at (A) 1, (B) 2, and (C) 4 u/mL.
PAK6 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: PAK6 Antibody - BSA Free [NBP1-76632] -

Immunocytochemistry/ Immunofluorescence: PAK6 Antibody - BSA Free [NBP1-76632] - Immunofluorescence of PAK6 in Raji cells with PAK6 antibody at 10 ug/mL.
PAK6 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: PAK6 Antibody - BSA Free [NBP1-76632] -

Immunocytochemistry/ Immunofluorescence: PAK6 Antibody - BSA Free [NBP1-76632] - Immunocytochemistry of PAK6 in Raji cells with PAK6 antibody at 10 ug/mL.

Applications for PAK6 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Western Blot

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PAK6

The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6. These proteins are not activated by Cdc42/Rac binding. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

Long Name

p21/Cdc42/Rac1-activated Kinase 6

Alternate Names

EC 2.7.11, p21 protein (Cdc42/Rac)-activated kinase 6, p21(CDKN1A)-activated kinase 6, p21-activated kinase 6, p21-activated protein kinase 6, PAK-5, PAK5EC 2.7.11.1, PAK-6, serine/threonine-protein kinase PAK 6

Gene Symbol

PAK6

UniProt

NP_064553 (Human)

Additional PAK6 Products

Product Documents for PAK6 Antibody - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PAK6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Intracellular Kinases

Citations for PAK6 Antibody - BSA Free

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Protocols

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FAQs

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