Palmitoylisopropylamide
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Description: Inhibitor of FAAH
Alternative Names: PIA
Chemical Name: N-(1-Methylethyl)-hexadecanamide
Biological Activity
Palmitoylisopropylamide is an inhibitor of fatty acid amide hydrolase (FAAH); pIC50 = 4.89 for inhibition of [3H]-anandamide metabolism. Displays little binding to CB1 and CB2 receptors (IC50 > 100 μM) and very weakly blocks anandamide uptake (IC50 ~ 100 μM). Inhibits proliferation of C6 glioma cells.Technical Data
M.Wt:
297.52
Formula:
C19H39NO
Solubility:
Soluble to 100 mM in ethanol and to 10 mM in DMSO
Storage:
Store at RT
CAS No:
189939-61-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide.
Jonsson et al.
Br.J.Pharmacol., 2001;133:1263 -
AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide.
Jonsson et al.
Arch.Toxicol., 2003;77:201
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