Pan Caspase Inhibitor Z-VAD-FMK

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Citations (195)
Reviews (3)

Pan Caspase Inhibitor Z-VAD-FMK Summary

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Citations for Pan Caspase Inhibitor Z-VAD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

195 Citations: Showing 1 - 10
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  1. AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
    Authors: L Tilokani, FM Russell, S Hamilton, DM Virga, M Segawa, V Paupe, AV Gruszczyk, M Protasoni, LC Tabara, M Johnson, H Anand, MP Murphy, DG Hardie, F Polleux, J Prudent
    Science Advances, 2022;8(45):eabo7956.  2022
  2. Magmas Inhibition in Prostate Cancer: A Novel Target for Treatment-Resistant Disease
    Authors: J Yang, BC Das, O Aljitawi, A Kumar, S Das, P Van Veldhu
    Cancers, 2022;14(11):.  2022
  3. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022;0(0):.  2022
  4. Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
    Authors: CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, C Clark, CH Earnshaw, MA Koufaki, E Bonavita, S Zelenay
    Nature Communications, 2022;13(1):2063.  2022
  5. Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L
    Authors: N Landi, S Ragucci, L Citores, A Clemente, HZF Hussain, R Iglesias, JM Ferreras, A Di Maro
    Toxins, 2022;14(8):.  2022
  6. DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
    Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
    Science Advances, 2022;8(34):eabn5522.  2022
  7. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
    Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
    Cell Death & Disease, 2022;13(2):145.  2022
  8. Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling
    Authors: JH Kim, S Hwang, JH Lee, SS Im, J Son
    International Journal of Molecular Sciences, 2022;23(20):.  2022
  9. Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
    Authors: SM Woo, S Kim, SU Seo, S Kim, JW Park, G Kim, YR Choi, K Hur, TK Kwon
    Cell Death & Disease, 2022;13(9):821.  2022
  10. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
    Authors: G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee
    Scientific Reports, 2022;12(1):22484.  2022
  11. TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
    Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
    Cells, 2022;11(20):.  2022
  12. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
    Authors: B Lee, Y Oh, E Cho, A DiAntonio, V Cavalli, JE Shin, HW Choi, Y Cho
    The Journal of Biological Chemistry, 2022;0(0):101647.  2022
  13. ABT?737, a Bcl?2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis
    Authors: R Cheng, X Liu, Z Wang, K Tang
    Molecular Medicine Reports, 2021;23(6):.  2021
  14. N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
    Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
    International Journal of Molecular Sciences, 2021;22(14):.  2021
  15. Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice
    Authors: M Tsubota, T Miyazaki, Y Ikeda, Y Hayashi, Y Aokiba, S Tomita, F Sekiguchi, D Wang, M Nishibori, A Kawabata
    Cells, 2021;10(10):.  2021
  16. PI3Kdelta coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T�cells at the expense of central memory
    Authors: JL Cannons, AV Villarino, SM Kapnick, S Preite, HY Shih, J Gomez-Rodr, Z Kaul, H Shibata, JM Reilley, B Huang, R Handon, IT McBain, S Gossa, T Wu, HC Su, DB McGavern, JJ O'Shea, PJ McGuire, G Uzel, PL Schwartzbe
    Cell Reports, 2021;37(2):109804.  2021
  17. The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
    Authors: DC Kanellis, JA Espinoza, A Zisi, E Sakkas, J Bartkova, AM Katsori, J Boström, L Dyrskjøt, H Broholm, M Altun, SJ Elsässer, MS Lindström, J Bartek
    Science Advances, 2021;7(32):.  2021
  18. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
    Authors: C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, B Fang, MV Poyurovsky, K Olszewski, B Gan
    Nature, 2021;0(0):.  2021
  19. Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
    Authors: K Wu, SM Woo, SU Seo, TK Kwon
    International Journal of Molecular Sciences, 2021;22(18):.  2021
  20. Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
    Authors: TW Kim, HG Lee
    International Journal of Molecular Sciences, 2021;22(24):.  2021
  21. Apoptosis Enhances the Replication of Human Coronavirus OC43
    Authors: S Maharjan, M Kang, J Kim, D Kim, S Park, M Kim, K Baek, Y Lee, HJ Kwon
    Viruses, 2021;13(11):.  2021
  22. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
    Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
    Embo Molecular Medicine, 2021;0(0):e14511.  2021
  23. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis
    Authors: Y Yao, Z Chen, H Zhang, C Chen, M Zeng, J Yunis, Y Wei, Y Wan, N Wang, M Zhou, C Qiu, Q Zeng, HS Ong, H Wang, FV Makota, Y Yang, Z Yang, N Wang, J Deng, C Shen, Y Xia, L Yuan, Z Lian, Y Deng, C Guo, A Huang, P Zhou, H Shi, W Zhang, H Yi, D Li, M Xia, J Fu, N Wu, JB de Haan, N Shen, W Zhang, Z Liu, D Yu
    Nature Immunology, 2021;22(9):1127-1139.  2021
  24. AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells
    Authors: HS Gil, JH Lee, AK Farag, AHE Hassan, KS Chung, JH Choi, EJ Roh, KT Lee
    Oncogene, 2021;13(22):.  2021
  25. Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T�cell subsets in�vivo
    Authors: G Xie, X Luo, T Ma, J Frouard, J Neidleman, R Hoh, SG Deeks, WC Greene, NR Roan
    Cell Reports, 2021;35(4):109038.  2021
  26. Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
    Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
    International Journal of Molecular Sciences, 2021;23(1):.  2021
  27. Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
    Authors: Y Li, T Tang, HJ Lee, K Song
    International Journal of Molecular Sciences, 2021;22(8):.  2021
  28. 3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms
    Authors: M Kosic, V Paunovic, B Ristic, A Mircic, M Bosnjak, D Stevanovic, T Kravic-Ste, V Trajkovic, L Harhaji-Tr
    Journal of pharmacological sciences, 2021;147(1):156-167.  2021
  29. Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer
    Authors: MS Jeong, KW Lee, YJ Choi, YG Kim, HH Hwang, SY Lee, SE Jung, SA Park, JH Lee, YJ Joo, SG Cho, SG Ko
    International Journal of Molecular Sciences, 2021;22(16):.  2021
  30. Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity
    Authors: N Ustyanovsk, G Choukrani, E Ammatuna, T Niki, E Cendrowicz, HJ Lourens, G Huls, VR Wiersma, E Bremer
    Biomedicines, 2021;10(1):.  2021
  31. Parabens disrupt non-canonical inflammasome activation
    Authors: H Ahn, H Lee, G Lee, J Park, HW Sung, E Lee, GS Lee
    International immunopharmacology, 2021;101(0):108196.  2021
  32. Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies
    Authors: G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye
    Science Advances, 2021;7(16):.  2021
  33. Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates
    Authors: P Van Damme
    International Journal of Molecular Sciences, 2021;22(19):.  2021
  34. Dual role of phosphatidylserine and its receptors in osteoclastogenesis
    Authors: JH Kang, HM Ko, GD Han, SY Lee, JS Moon, MS Kim, JT Koh, SH Kim
    Cell Death Dis, 2020;11(7):497.  2020
  35. Energy-stress-mediated AMPK activation inhibits ferroptosis
    Authors: H Lee, F Zandkarimi, Y Zhang, JK Meena, J Kim, L Zhuang, S Tyagi, L Ma, TF Westbrook, GR Steinberg, D Nakada, BR Stockwell, B Gan
    Nat. Cell Biol., 2020;22(2):225-234.  2020
  36. Combination of Arsenic Trioxide and Valproic Acid Efficiently Inhibits Growth of Lung Cancer Cells via G2/M-Phase Arrest and Apoptotic Cell Death
    Authors: HK Park, BR Han, WH Park
    Int J Mol Sci, 2020;21(7):.  2020
  37. Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma
    Authors: J Wang, K Sato, E O'Donnell, A Singla, S Yaguare, O Aldahamshe, B Batko, H Borjihan, J Tingling, J Zhang, DA Weiser, DM Loeb, R Gorlick, EL Schwartz, R Yang, X Zi, H Zhao, DS Geller, BH Hoang
    Transl Oncol, 2020;13(10):100809.  2020
  38. Activation of JNK signaling promotes all-trans retinal-induced photoreceptor apoptosis in mice
    Authors: C Liao, B Cai, Y Feng, J Chen, Y Wu, J Zhuang, Z Liu, Y Wu
    J. Biol. Chem., 2020;0(0):.  2020
  39. Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines
    Authors: CA Iannuzzi, P Indovina, IM Forte, S Di Somma, AM Malfitano, M Bruno, G Portella, F Pentimalli, A Giordano
    Int J Mol Sci, 2020;21(19):.  2020
  40. PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
    Authors: JE Jang, JI Eom, HK Jeung, H Chung, YR Kim, JS Kim, JW Cheong, YH Min
    J. Exp. Clin. Cancer Res., 2020;39(1):66.  2020
  41. Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein
    Authors: R Liu, X Wang, C Curtiss, MS Sheikh, Y Huang
    Cell Death Differ., 2020;0(0):.  2020
  42. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020;10(1):7489.  2020
  43. BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
    Authors: J Mann, N Yang, R Montpetit, R Kirschenma, H Lemieux, IS Goping
    Sci Rep, 2020;10(1):355.  2020
  44. Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-&kappaB and PI3K/Akt/mTOR Signaling Pathways
    Authors: Y Xu, X Feng, Q Zhou, W Jiang, Y Dai, Y Jiang, X Liu, S Li, Y Wang, F Wang, A Li, C Zheng
    OncoTargets and Therapy, 2020;13(0):13063-13075.  2020
  45. Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
    Authors: A Murai, S Ebara, S Sasaki, T Ohashi, T Miyazaki, T Nomura, S Araki
    PLoS ONE, 2020;15(10):e0240718.  2020
  46. Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
    Authors: KM Lee, H Lee, D Han, WK Moon, K Kim, HJ Oh, J Choi, EH Hwang, SE Kang, SA Im, KH Lee, HS Ryu
    Breast Cancer Res, 2020;22(1):130.  2020
  47. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020;31(13):107839.  2020
  48. Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling
    Authors: IH Yang, SH Hong, M Jung, CH Ahn, HJ Yoon, SD Hong, SD Cho, JA Shin
    Cancer Cell Int., 2020;20(0):405.  2020
  49. Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
    Authors: SA Shahriyar, SU Seo, KJ Min, P Kubatka, DS Min, JS Chang, DE Kim, SM Woo, TK Kwon
    Cancers (Basel), 2020;12(9):.  2020
  50. Involvement of the NF-&kappaB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells
    Authors: JH Kim, Y Youn, JC Lee, J Kim, JH Hwang
    Journal of Cancer, 2020;11(19):5601-5611.  2020
  51. Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium
    Authors: F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama, H Nagasawa, N Kohyama, Y Okazaki, S Akatsuka, S Toyokuni
    Redox Biol, 2020;36(0):101616.  2020
  52. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
    Authors: PC Hsu, CF Cheng, PC Hsieh, YH Chen, CY Kuo, HK Sytwu
    Evid Based Complement Alternat Med, 2020;2020(0):5867064.  2020
  53. Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells
    Authors: Q Zhong, TI Roumelioti, Z Kozik, M Cepeda-Mol, LÁ Fernández, AR Shenoy, C Bakal, G Frankel, JS Choudhary
    PloS Biology, 2020;18(12):e3000986.  2020
  54. Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
    Authors: KJ Min, TK Kwon
    Cancers (Basel), 2020;12(11):.  2020
  55. Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death
    Authors: SY Park, HH Park, SY Park, SM Hong, S Yoon, MJ Morgan, YS Kim
    Cell Death Dis, 2020;11(9):744.  2020
  56. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020;60(0):102984.  2020
  57. The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1
    Authors: SP O'Hara, PL Splinter, CE Trussoni, E Guicciardi, NP Splinter, MS Al Suraih, N Nasser-Gho, D Stollenwer, GJ Gores, NF LaRusso
    J. Biol. Chem., 2019;0(0):.  2019
  58. Therapeutic efficacy of a novel ?III/?IV-tubulin inhibitor (VERU-111) in pancreatic cancer
    Authors: VK Kashyap, Q Wang, S Setua, PKB Nagesh, N Chauhan, S Kumari, P Chowdhury, DD Miller, MM Yallapu, W Li, M Jaggi, BB Hafeez, SC Chauhan
    J. Exp. Clin. Cancer Res., 2019;38(1):29.  2019
  59. N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
    Authors: D Yamasoba, K Sato, T Ichinose, T Imamura, L Koepke, S Joas, E Reith, D Hotter, N Misawa, K Akaki, T Uehata, T Mino, S Miyamoto, T Noda, A Yamashita, DM Standley, F Kirchhoff, D Sauter, Y Koyanagi, O Takeuchi
    Nat Microbiol, 2019;0(0):.  2019
  60. Caspase-1 initiates apoptosis in the absence of gasdermin D
    Authors: K Tsuchiya, S Nakajima, S Hosojima, D Thi Nguyen, T Hattori, T Manh Le, O Hori, MR Mahib, Y Yamaguchi, M Miura, T Kinoshita, H Kushiyama, M Sakurai, T Shiroishi, T Suda
    Nat Commun, 2019;10(1):2091.  2019
  61. Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
    Authors: SM Woo, KJ Min, SU Seo, S Kim, P Kubatka, JW Park, TK Kwon
    Int J Mol Sci, 2019;20(13):.  2019
  62. Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77
    Authors: PR Mittelstad, MD Taves, JD Ashwell
    J. Immunol., 2019;0(0):.  2019
  63. Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis
    Authors: J Riegger, RE Brenner
    Cell Death Dis, 2019;10(10):683.  2019
  64. Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5
    Authors: SJ Choi, CH Ahn, IH Yang, B Jin, WW Lee, JH Kim, MH Ahn, N Swarup, KO Hong, JA Shin, NT Woo, SD Hong, JI Lee, SD Cho
    Molecules, 2019;24(20):.  2019
  65. Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells
    Authors: HD Cho, HJ Min, YS Won, HY Ahn, YS Cho, KI Seo
    BMC Complement Altern Med, 2019;19(1):241.  2019
  66. Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis
    Authors: R Madhi, M Rahman, D Taha, J Linders, M Merza, Y Wang, M Mörgelin, H Thorlacius
    JCI Insight, 2019;0(0):.  2019
  67. Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A
    Authors: M Dileepan, XN Ge, I Bastan, YG Greenberg, Y Liang, P Sriramarao, SP Rao
    J. Immunol., 2019;0(0):.  2019
  68. Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca2+ Overload
    Authors: AR Lee, MJ Seo, J Kim, DM Lee, IY Kim, MJ Yoon, H Hoon, KS Choi
    Int J Mol Sci, 2019;20(24):.  2019
  69. Non-SMC condensin I complex subunit H mediates mature chromosome condensation and DNA damage in pancreatic cancer cells
    Authors: JH Kim, Y Youn, KT Kim, G Jang, JH Hwang
    Sci Rep, 2019;9(1):17889.  2019
  70. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
    Authors: S Yan, N Zhou, D Zhang, K Zhang, W Zheng, Y Bao, W Yang
    Int J Mol Sci, 2019;20(21):.  2019
  71. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin
    Authors: DE Kim, MET Dollé, WP Vermeij, A Gyenis, K Vogel, JHJ Hoeijmaker, CD Wiley, AR Davalos, P Hasty, PY Desprez, J Campisi
    Aging Cell, 2019;0(0):e13072.  2019
  72. Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
    Authors: SU Seo, KJ Min, SM Woo, TK Kwon
    Exp. Mol. Med., 2018;50(8):107.  2018
  73. Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
    Authors: JM Yun, SM Woo, SU Seo, KJ Min, DE Kim, TK Kwon
    Molecules, 2018;23(9):.  2018
  74. BAP1 links metabolic regulation of ferroptosis to tumour suppression
    Authors: Y Zhang, J Shi, X Liu, L Feng, Z Gong, P Koppula, K Sirohi, X Li, Y Wei, H Lee, L Zhuang, G Chen, ZD Xiao, MC Hung, J Chen, P Huang, W Li, B Gan
    Nat. Cell Biol., 2018;0(0):.  2018
  75. Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury
    Authors: Z Zhang, X Shao, N Jiang, S Mou, L Gu, S Li, Q Lin, Y He, M Zhang, W Zhou, Z Ni
    Cell Death Dis, 2018;9(10):983.  2018
  76. SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
    Authors: Y Yue, NR Nabar, CS Shi, O Kamenyeva, X Xiao, IY Hwang, M Wang, JH Kehrl
    Cell Death Dis, 2018;9(9):904.  2018
  77. Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells
    Authors: TW Kim, SY Lee, M Kim, C Cheon, SG Ko
    Cell Death Dis, 2018;9(9):875.  2018
  78. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription
    Authors: H Wang, J Lapek, K Fujimura, J Strnadel, B Liu, DJ Gonzalez, W Zhang, F Watson, V Yu, C Liu, CM Melo, YI Miller, KC Elliott, DA Cheresh, RL Klemke
    Cell Discov, 2018;4(0):26.  2018
  79. Integrin ?6?4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues
    Authors: SH Jung, M Lee, HA Park, HC Lee, D Kang, HJ Hwang, C Park, DM Yu, YR Jung, MN Hong, YN Kim, HJ Park, YG Ko, JS Lee
    Cell Death Differ., 2018;0(0):.  2018
  80. Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease
    Authors: WK Saeed, DW Jun, K Jang, SB Ahn, JH Oh, YJ Chae, JS Lee, HT Kang
    World J. Gastroenterol., 2018;24(48):5477-5490.  2018
  81. Induction of immunosuppressive functions and NF-?B by FLIP in monocytes
    Authors: A Fiore, S Ugel, F De Sanctis, S Sandri, G Fracasso, R Trovato, S Sartoris, S Solito, S Mandruzzat, F Vascotto, KL Hippen, G Mondanelli, U Grohmann, G Piro, C Carbone, D Melisi, RT Lawlor, A Scarpa, A Lamolinara, M Iezzi, M Fassan, S Bicciato, BR Blazar, U Sahin, PJ Murray, V Bronte
    Nat Commun, 2018;9(1):5193.  2018
  82. mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
    Authors: SU Seo, SM Woo, HS Lee, SH Kim, KJ Min, TK Kwon
    Oncogene, 2018;0(0):.  2018
  83. A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
    Authors: BN Singh, N Koyano-Nak, W Gong, IP Moskowitz, CV Weaver, E Braunlin, S Das, JH van Berlo, MG Garry, DJ Garry
    Nat Commun, 2018;9(1):4237.  2018
  84. Herbal formula YGJDSJ inhibits anchorage-independent growth and induces anoikis in hepatocellular carcinoma Bel-7402 cells
    Authors: B Hu, T Zhang, HM An, JL Zheng, X Yan, XW Huang
    BMC Complement Altern Med, 2018;18(1):17.  2018
  85. BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells
    Authors: JW Shin, SB Kwon, Y Bak, SK Lee, DY Yoon
    Sci China Life Sci, 2018;0(0):.  2018
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  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

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Pan Caspase Inhibitor Z-VAD-FMK
By Anonymous on 11/20/2020

Pan Caspase Inhibitor Z-VAD-FMK
By Anonymous on 08/17/2018

Pan Caspase Inhibitor Z-VAD-FMK
By Anonymous on 06/29/2017

M30 CytoDEATH in vitro staining of apoptosis induced by hydrogen peroxide.