An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50
of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
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A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
Fry et al.
PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
Bos et al.
Clin.Cancer Res., 1997;3:2099
Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
Bridges et al.
The citations listed below are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:
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