Catalog Number: 1037
Alternate Names: ZM 252868
Chemical Name: 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Biological Activity
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
Technical Data
  • M.Wt:
    396.67
  • Formula:
    C16H14BrN3O2.HCl
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    183322-45-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
    Fry et al.
    Science, 1994;265:1093
  2. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.
    Bos et al.
    Clin.Cancer Res., 1997;3:2099
  3. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
    Bridges et al.
    J.Med.Chem., 1996;39:267
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
    Authors: Swanson Et al.
    J Immunol 2012;188:3513

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