PD 153035 hydrochloride

  ( 3 citations )    
Product Datasheet
Catalog Number:1037
Alternate Names:ZM 252868
Chemical Name:4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride
Product Details
Citations (3)
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Reviews
Biological Activity
An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.
Technical Data
  • M.Wt:
    396.67
  • Formula:
    C16H14BrN3O2.HCl
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Storage:
    Store at RT
  • CAS No:
    183322-45-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 153035 hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.
    Authors: Lahey Et al.
    PLoS One  2017;12:e0180259
  2. Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition.
    Authors: Taylor Et al.
    Breast Cancer Res Treat  2014;144:551
  3. Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
    Authors: Swanson Et al.
    J Immunol  2012;188:3513

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