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Pentoxifylline

  ( 16 citations )    
Product Datasheet
Catalog Number:3056
Alternate Names:PTX
Chemical Name:3,7-Dimethyl-1-(5-oxohexyl)xanthine
Product Details
Citations (16)
Reviews
Biological Activity
Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.
Technical Data
  • M.Wt:
    278.31
  • Formula:
    C13H18N4O3
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    6493-05-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pentoxifylline include:

16 Citations: Showing 1 - 10
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  1. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal  2015;8:ra71
  2. β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
    Authors: Wang Et al.
    Mediators Inflamm  2015;5:7681
  3. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Toxicol Sci  2015;5:10468
  4. Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
    Authors: Guidi Et al.
    PLoS One  2015;35:3966
  5. Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus.
    Authors: Park
    J Neurosci  2015;2015:275126
  6. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.
    Authors: Simonson Et al.
    Mol Biol Cell  2015;172:515
  7. In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
    Authors: Thueson Et al.
    Sci Rep  2015;143:418
  8. Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.
    Authors: Malyshev Et al.
    PLoS One  2015;10:e0122286
  9. Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.
    Authors: Kumar and Foster
    J Neurosci  2013;33:15710
  10. Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.
    Authors: Bailes Et al.
    Dev Neurobiol  2012;7:e30774
  11. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    Neuroscience  2011;71:221
  12. Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
    Authors: Zhang Et al.
    Br J Pharmacol  2011;174:45931
  13. Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
    Authors: Zhao Et al.
    J Physiol  2010;588:2605
  14. Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically.
    Authors: Penzo and Peña
    J Neurosci  2009;29:4131
  15. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
    Neuron  2006;52:1047
  16. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J  2004;23:3031
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