Discontinued Product

3056 has been discontinued.
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Pentoxifylline | CAS No. 6493-05-6 | Phosphodiesterase Inhibitors
1 Image
Description: PDE inhibitor
Alternative Names: PTX

Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine

Purity: ≥99%

Product Details
Citations (18)

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Pentoxifylline

The citations listed below are publications that use Tocris products. Selected citations for Pentoxifylline include:

18 Citations: Showing 1 - 10

  1. Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
    Authors: Wang Et al.
    J Clin Invest  2017;127:1978
  2. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal  2015;8:ra71
  3. β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
    Authors: Wang Et al.
    Mediators Inflamm  2015;5:7681
  4. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Toxicol Sci  2015;5:10468
  5. Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
    Authors: Guidi Et al.
    PLoS One  2015;35:3966
  6. Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus.
    Authors: Park
    J Neurosci  2015;2015:275126
  7. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.
    Authors: Simonson Et al.
    Mol Biol Cell  2015;172:515
  8. In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
    Authors: Thueson Et al.
    Sci Rep  2015;143:418
  9. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings.
    Authors: Feng Et al.
    J Neurophysiol  2015;113:2618
  10. Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.
    Authors: Malyshev Et al.
    PLoS One  2015;10:e0122286


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