Catalog Number: 3056
Alternate Names: PTX
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine
Biological Activity
Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450.
    Monshouwer et al.
    Biochem.Pharmacol., 1996;52:1195
  2. Antihyperalgesic effect of pentoxifylline on experimental inflammatory pain.
    Vale et al.
    Br.J.Pharmacol., 2004;143:833

The citations listed below are publications that use Tocris products. Selected citations for Pentoxifylline include:

Showing Results 1 - 10 of 14

  1. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal
  2. β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
    Authors: Wang Et al.
    Mediators Inflamm
  3. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Toxicol Sci
  4. Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
    Authors: Guidi Et al.
    PLoS One
  5. Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus.
    Authors: Park
    J Neurosci
  6. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.
    Authors: Simonson Et al.
    Mol Biol Cell
  7. In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
    Authors: Thueson Et al.
    Sci Rep
  8. Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.
    Authors: Malyshev Et al.
    PLoS One
  9. Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.
    Authors: Bailes Et al.
    Dev Neurobiol
  10. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
  11. Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
    Authors: Zhang Et al.
    Br J Pharmacol
  12. Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically.
    Authors: Penzo and Peña
    J Neurosci
  13. Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
    Authors: Jakubs Et al.
  14. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J
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