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Pentoxifylline

3056 18 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3056/50
Cat.No. 3056 - Pentoxifylline | C13H18N4O3 | CAS No. 6493-05-6
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Description: PDE inhibitor
Alternative Names: PTX

Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine

Purity: ≥99%

Product Details
Citations (18)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.

Technical Data

M.Wt:
278.31
Formula:
C13H18N4O3
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
6493-05-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citations for Pentoxifylline

The citations listed below are publications that use Tocris products. Selected citations for Pentoxifylline include:

18 Citations: Showing 1 - 10

  1. Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
    Authors: Wang Et al.
    J Clin Invest  2017;127:1978
  2. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
    Authors: Liu Et al.
    Sci Signal  2015;8:ra71
  3. β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
    Authors: Wang Et al.
    Mediators Inflamm  2015;5:7681
  4. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Toxicol Sci  2015;5:10468
  5. Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
    Authors: Guidi Et al.
    PLoS One  2015;35:3966
  6. Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus.
    Authors: Park
    J Neurosci  2015;2015:275126
  7. Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.
    Authors: Simonson Et al.
    Mol Biol Cell  2015;172:515
  8. In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
    Authors: Thueson Et al.
    Sci Rep  2015;143:418
  9. Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings.
    Authors: Feng Et al.
    J Neurophysiol  2015;113:2618
  10. Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.
    Authors: Malyshev Et al.
    PLoS One  2015;10:e0122286

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