Pentoxifylline
Chemical Name: 3,7-Dimethyl-1-(5-oxohexyl)xanthine
Purity: ≥99%
Biological Activity
Phosphodiesterase inhibitor that blocks production of TNF-α and other cytokines. Displays antinociceptive activity.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antihyperalgesic effect of pentoxify. on experimental inflammatory pain.
Vale et al.
Br.J.Pharmacol., 2004;143:833 -
Differential effect of pentoxify. on lipopolysaccharide-induced downregulation of cytochrome P450.
Monshouwer et al.
Biochem.Pharmacol., 1996;52:1195
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Citations for Pentoxifylline
The citations listed below are publications that use Tocris products. Selected citations for Pentoxifylline include:
18 Citations: Showing 1 - 10
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Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
Authors: Wang Et al.
J Clin Invest 2017;127:1978
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A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.
Authors: Liu Et al.
Sci Signal 2015;8:ra71
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β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.
Authors: Wang Et al.
Mediators Inflamm 2015;5:7681
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GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Authors: Zhang Et al.
Toxicol Sci 2015;5:10468
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Impaired attention and synaptic senescence of the prefrontal cortex involves redox regulation of NMDA receptors.
Authors: Guidi Et al.
PLoS One 2015;35:3966
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Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus.
Authors: Park
J Neurosci 2015;2015:275126
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Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.
Authors: Simonson Et al.
Mol Biol Cell 2015;172:515
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In vitro exposure to the herbicide atrazine inhibits T cell activation, proliferation, and cytokine production and significantly increases the frequency of Foxp3+ regulatory T cells.
Authors: Thueson Et al.
Sci Rep 2015;143:418
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Experimental and computational evidence for an essential role of NaV1.6 in spike initiation at stretch-sensitive colorectal afferent endings.
Authors: Feng Et al.
J Neurophysiol 2015;113:2618
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Advantages and limitations of the use of optogenetic approach in studying fast-scale spike encoding.
Authors: Malyshev Et al.
PLoS One 2015;10:e0122286
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Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.
Authors: Kumar and Foster
J Neurosci 2013;33:15710
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Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.
Authors: Bailes Et al.
Dev Neurobiol 2012;7:e30774
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Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
Authors: Zhang and Sun
Neuroscience 2011;71:221
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Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
Authors: Zhang Et al.
Br J Pharmacol 2011;174:45931
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Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Authors: Zhao Et al.
J Physiol 2010;588:2605
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Endocannabinoid-mediated long-term depression in the avian midbrain expressed presynaptically and postsynaptically.
Authors: Penzo and Peña
J Neurosci 2009;29:4131
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Environment matters: synaptic properties of neurons born in the epileptic adult brain develop to reduce excitability.
Authors: Jakubs Et al.
Neuron 2006;52:1047
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PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
Authors: Pierre Et al.
EMBO J 2004;23:3031
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