Perifosine

Catalog # Availability Size / Price Qty
6087/50
6087/10

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Perifosine | CAS No. 157716-52-4 | Akt (Protein Kinase B) Inhibitors
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Description: PKB/Akt inhibitor; also modulates Kv2.1 current
Alternative Names: KRX-0401

Chemical Name: Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

Technical Data

M.Wt:
461.66
Formula:
C25H52NO4P
Solubility:
Soluble to 100 mM in water and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
157716-52-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Perifosine

The citations listed below are publications that use Tocris products. Selected citations for Perifosine include:

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