Perifosine

Key Product Details

Product Description

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases K_v2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

Product Specifications for Perifosine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Perifosine

The following data is based on the product molecular weight 461.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.66 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Fu Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009 PMID: 19920197
• Tazzari Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 2008 PMID: 19010914
• Delgado-Ramírez Modulation of the voltage-gated potassium channel K_v2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 2016 PMID: 26922553

Product Documents for Perifosine