PF 03814735

Tocris Bioscience | Catalog # 4821

Aurora kinase A and B inhibitor
Tocris Bioscience
Discontinued Product
4821 has been discontinued. View all Aurora Kinase Inhibitors products.

Key Product Details

Description

Aurora kinase A and B inhibitor
View all Aurora Kinase Inhibitors »

Product Description

PF 03814735 is an ATP-competitive inhibitor of Aurora kinases A and B (IC50 values are 0.8 and 5 nM for recombinant Aurora B and Aurora A, respectively). Inhibits phosphorylation of Aurora B, histone H3 and Aurora A in cultured MDA-MB-231 cells (IC50 values are approximately 20, 50 and 150 nM respectively). Shown to block cytokinesis; inhibits cellular proliferation in several human tumor cell lines, including HCT-116, HL-60, A549 and H125, and in human xenograft mouse models. Also enhances adeno-associated virus transduction of retina cells in vitro and in vivo. Orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 03814735

Molecular Weight

474.48

Formula

C23H25F3N6O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide

CAS Number

942487-16-3

PubChem ID

51346455

InChI Key

RYYNGWLOYLRZLK-RBUKOAKNSA-N

SMILES

[H][C@@]3(N5C(CNC(C)=O)=O)CC[C@@]5([H])C(C3=C4)=CC=C4NC1=NC(NC2CCC2)=C(C(F)(F)F)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.45 100
Ethanol 9.49 20

Preparing Stock Solutions for PF 03814735

The following data is based on the product molecular weight 474.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.11 mL 10.54 mL 21.08 mL
5 mM 0.42 mL 2.11 mL 4.22 mL
10 mM 0.21 mL 1.05 mL 2.11 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 03814735

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 03814735

For research use only

Related Research Areas

Cell Cycle
Epigenetics

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