PF 06551600 malonate

Catalog # Availability Size / Price Qty
6506/5
6506/25
Cat.No. 6506 - PF 06651600 malonate | C15H19N5O.C3H4O4 | CAS No. 2140301-97-7
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Description: Potent and selective JAK3 inhibitor

Chemical Name: 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective JAK3 inhibitor (IC50 = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

Technical Data

M.Wt:
389.41
Formula:
C15H19N5O.C3H4O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2140301-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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