PF 429242

  ( 3 citations )    
Product Datasheet
Catalog Number:3354
Chemical Name:4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide
Product Details
Citations (3)
Reviews
Biological Activity
Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM). Also displays antiviral activity. Cell permeable.
Technical Data
  • M.Wt:
    482.49
  • Formula:
    C25H35N3O2.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 50 mM in DMSO
  • Purity:
    >97
  • Storage:
    Desiccate at RT
  • CAS No:
    947303-87-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 429242 include:

3 Citations: Showing 1 - 3
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  1. Suppressive effects of the site 1 protease (S1P) inhibitor, PF-429242, on dengue virus propagation.
    Authors: Uchida Et al.
    Viruses  2016;8:E46
  2. Analysis of Assembly and Budding of Lujo Virus.
    Authors: Urata Et al.
    J Virol  2015;90:3257
  3. Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion.
    Authors: Kleinfelter Et al.
    Ann Rheum Dis  2015;6:e00801

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