Potent and selective inhibitor of focal adhesion kinase (FAK) (IC50
= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover in vitro
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Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
FAK-heterozygous mice display enhanced tumour angiogenesis.
Kostourou et al.
Cellular characterization of a novel focal adhesion kinase inhibitor.
Slack-Davis et al.
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