PGD2 Synthase/PTGDS Antibody - BSA Free

Novus Biologicals | Catalog # NB110-59909

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Equine, Feline, Fish, Primate, Rabbit

Cited:

Human, Fish

Applications

Validated:

Western Blot, Simple Western

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all PGD2 Synthase/PTGDS Primary Antibodies »

Product Specifications

Immunogen

The epitope recognized by this antibody maps to region within residue 25-100 of human Prostaglandin D Synthase/Lipocalin. [Swiss-Prot# P41222]

Reactivity Notes

Fish reactivity reported in scientific literature (PMID: 31401171).

Localization

Endoplasmic reticulum; rough endoplasmic reticulum. Nucleus; nuclear membrane. Golgi apparatus. Cytoplasm; perinuclear region. Secreted protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for PGD2 Synthase/PTGDS Antibody - BSA Free

Western Blot: PGD2 Synthase/PTGDS AntibodyBSA Free [NB110-59909]

Western Blot: PGD2 Synthase/PTGDS AntibodyBSA Free [NB110-59909]

Western Blot: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Detection of Prostaglandin D Synthase/Lipocalin in human brain lysates (NB820-59177) using NB110-59909.
Simple Western: PGD2 Synthase/PTGDS AntibodyBSA Free [NB110-59909]

Simple Western: PGD2 Synthase/PTGDS AntibodyBSA Free [NB110-59909]

Simple Western: PGD2 Synthase/PTGDS Antibody [NB110-59909] - Simple Western lane view shows a specific band for PGD2/Synthase/PTGDS in 0.5 mg/ml of Human Brain lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Applications for PGD2 Synthase/PTGDS Antibody - BSA Free

Application
Recommended Usage

Simple Western

1:50

Western Blot

2 ug/ml
Application Notes

This Prostaglandin D Synthase/Lipocalin antibody is useful for Western blot analysis where a band can be seen at approx. 21 kDa.

In Simple Western only 10 - 15 uL of the recommended dilution is used per data point.
See Simple Western Antibody Database for Simple Western validation: Tested in Human Brain lysate 0.5 mg/mL, separated by Size, antibody dilution of 1:50, apparent MW was 49 kDa. Separated by Size-Wes, Sally Sue/Peggy Sue.
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS and 30% Glycerol

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PGD2 Synthase/PTGDS

Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers.

Long Name

Prostaglandin D2 Synthase

Alternate Names

Cerebrin-28, PDS, PGD2, PGDS2, PH2DISO, PTGDS

Gene Symbol

PTGDS

Additional PGD2 Synthase/PTGDS Products

Product Documents for PGD2 Synthase/PTGDS Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for PGD2 Synthase/PTGDS Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for PGD2 Synthase/PTGDS Antibody - BSA Free

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