PGLYRP1/PGRP-S Antibody

Novus Biologicals | Catalog # NBP1-20962

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all PGLYRP1/PGRP-S Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-PGNQLYHLIQN corresponding to C-Terminus according to NP_005082.1.

Epitope

C-PGNQLYHLIQN

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PGLYRP1/PGRP-S Antibody

Western Blot: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Western Blot: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Western Blot: PGLYRP1/PGRP-S Antibody [NBP1-20962] - Staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962] - Human spleen. Image submitted by a verified customer review.
Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962]

Immunohistochemistry-Paraffin: PGLYRP1/PGRP-S Antibody [NBP1-20962] - Staining of Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for PGLYRP1/PGRP-S Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 6 ug/ml

Immunohistochemistry-Paraffin

3 - 6 ug/ml

Peptide ELISA

Detection limit 1:4000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 30 kDa band observed in Jurkat lysates is reported in scientific literature (PMID: 16354652). IHC-P: Human spleen shows staining of select splenocytes.

Reviewed Applications

Read 1 review rated 4 using NBP1-20962 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PGLYRP1/PGRP-S

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein (5). However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50

Long Name

Peptidoglycan Recognition Protein Short/Peptidoglycan Recognition Protein 1

Alternate Names

PGRP-S, PGRPS, TAG7, TNFSF3L

Entrez Gene IDs

8993 (Human)

Gene Symbol

PGLYRP1

UniProt

NP_005082.1 (Human)

Additional PGLYRP1/PGRP-S Products

Product Documents for PGLYRP1/PGRP-S Antibody

Certificate of Analysis

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Product Specific Notices for PGLYRP1/PGRP-S Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Host Defense/Innate Immunity

Citations for PGLYRP1/PGRP-S Antibody

Customer Reviews for PGLYRP1/PGRP-S Antibody (1)

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1 Customer Rating
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  • Name: Carol Bain
    Application: Immunohistochemistry-Paraffin
    Sample Tested: Human spleen, FFPE
    Species: Human
    Verified Customer | Posted 05/29/2014
    1:200, human spleen, formalin fixed paraffin embedded. Sodium Citrate pH 6 (heat induced epitope retrieval)
    PGLYRP1/PGRP-S Antibody NBP1-20962

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