PHA 665752

Tocris Bioscience | Catalog # 2693

Potent and selective MET inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective MET inhibitor
View all MET Inhibitors »

Product Description

PHA 665752 is a potent, selective and ATP-competitive inhibitor of MET kinase (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PHA 665752

Molecular Weight

641.61

Formula

C32H34Cl2N4O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine

CAS Number

477575-56-7

PubChem ID

10461815

InChI Key

OYONTEXKYJZFHA-SSHUPFPWSA-N

SMILES

ClC1=C(CS(C2=CC(/C(C(N4)=O)=C/C3=C(C)C(C(N5CCC[C@@H]5CN6CCCC6)=O)=C(C)N3)=C4C=C2)(=O)=O)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.16 100

Preparing Stock Solutions for PHA 665752

The following data is based on the product molecular weight 641.61.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.56 mL 7.79 mL 15.59 mL
5 mM 0.31 mL 1.56 mL 3.12 mL
10 mM 0.16 mL 0.78 mL 1.56 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 110 publications citing the usage of this product.

Product Documents for PHA 665752

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PHA 665752

For research use only

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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