Catalog Number: 1027
Chemical Name: N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
Biological Activity
Group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.
Technical Data
  • M.Wt:
    294.31
  • Formula:
    C17H14N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    179068-02-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under license from Suntory Ltd.
Background References
  1. Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum.
    Mao and Wang
    Synapse, 2001;39:82
  2. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.
    Marino et al.
    Proc.Natl.Acad.Sci.USA, 2003;100:13668
  3. Positive allosteric modulators of metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization.
    Flor et al.
    Neuropharmacology, 2002;43:286 Abstr.No. 47
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PHCCC include:

3 Citations: Showing 1 - 3
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  1. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
    Authors: Spampinato Et al.
    Biol Psychiatry 2015;8:462
  2. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
    Authors: Broadstock Et al.
    Br J Pharmacol 2012;165:1034
  3. Neutrophil-derived glutamate regulates vascular endothelial barrier function.
    Authors: Collard Et al.
    J Biol Chem 2002;277:14801

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