Group I metabotropic glutamate receptor antagonist (IC50
~ 3 μ
M); 67 times more potent than (S)-4-carboxyphenylglycine
(Cat. No. 0323). Also a positive allosteric modulator for mGlu4a
; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro
. Displays antiParkinsonian effects in rats in vivo
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Sold for research purposes under license from Suntory Ltd.
Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum.
Mao and Wang
Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.
Marino et al.
A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates.
Annoura et al.
The citations listed below are publications that use Tocris products. Selected citations for PHCCC include:
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