Chemical Name: N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
Biological ActivityPHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 μM); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro. Displays antiParkinsonian effects in rats in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P and preproenkephalin mRNA expression in rat dorsal striatum.
Mao and Wang
Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment.
Marino et al.
A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates.
Annoura et al.
Positive allosteric modulators of metabotropic glutamate receptor subtype 4: pharmacological and molecular characterization.
Flor et al.
Neuropharmacology, 2002;43:286 Abstr.No. 47
Citations for PHCCC
The citations listed below are publications that use Tocris products. Selected citations for PHCCC include:
8 Citations: Showing 1 - 8
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.
Authors: Volpi Et al.
Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes.
Authors: Spampinato Et al.
Biol Psychiatry 2015;8:462
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
Authors: Broadstock Et al.
Br J Pharmacol 2012;165:1034
Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (
Authors: Jones Et al.
J Med Chem 2011;54:7639
mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum.
Front Neurosci 2009;3:46
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Authors: Niswender Et al.
Mol Pharmacol 2008;74:1345
A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators.
Authors: Hemstapat Et al.
Mol Pharmacol 2006;70:616
Neutrophil-derived glutamate regulates vascular endothelial barrier function.
Authors: Collard Et al.
J Biol Chem 2002;277:14801
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